Modeling of pharmaceutical propagation and parameter generation for injection protocols
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A technology of parameter and contrast agent transfer, applied in the direction of drug device, medical simulation, device introduced into the body, etc., to achieve the effect of increasing consistency, reducing the number of retakes, and reducing image artifacts
Inactive Publication Date: 2013-07-24
BAYER HEALTHCARE LLC
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[0089] As used herein and in the appended claims, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. Thus, for example, a reference to "a parameter" includes a plurality of such parameters and their equivalents known to those skilled in the art, and so on, a reference to "the parameter" is a reference to one or more of such parameters. references to parameters and their equivalent parameters known to those skilled in the art, and so on.
[0090] In several representative embodiments, a physiologically based pharmacokinetic or PBPK modeling paradigm is used. In many embodiments, the PBPK model can eg be converted to the discrete time domain. Furthermore, many embodiments of the model will provide an explicit incorporation in the pharmacokinetics of transport delays (that is, transit times, eg, of contrast agents through the pulmonary vasculature). The distribution of drugs in the vascular structures throughout the b...
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Abstract
A system includes a parameter generation system to determine at least one parameter for an injection procedure (for example, a parameter of an injection protocol or an imaging system parameter), the parameter generator system includes a physiologically based pharmacokinetic model to model propagation of a contrast medium injected into a patient including at least one of a non-linear saturation term in a peripheral venous compartment, at least one configurable transport delay term through at least one compartment, or an adaptation to model volumetric flow rate of blood and an effect thereof on the propagation of contrast medium after injection of contrast medium ceases. The physiologically based pharmacokinetic model can, for example, be discretizable.
Description
[0001] related application [0002] This application claims the benefit of U.S. Provisional Application Serial No. 61 / 358,400, filed June 24, 2010, and also contains subject matter that may be related to that disclosed and / or claimed in the following application: March 22, 2007 U.S. Patent Application No. 11 / 575,846 filed March 27, 2007, U.S. Patent Application No. 11 / 576,060 filed March 27, 2007 (now issued as U.S. Patent 7,925,330), U.S. Patent Application No. 12 / 519,040, filed June 12, 2009, U.S. Patent Application No. 12 / 519.213, filed June 15, 2009, and U.S. Patent Application No. 12 / 669,292, filed January 15, 2010, which The disclosure of is incorporated herein by reference and forms a part of this document. Background technique [0003] The following information is provided to assist the reader in understanding the techniques described below and some of the circumstances in which such techniques may be used. The terms used herein are not intended to be limited to any ...
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