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Modeling of drug delivery and parameter generation of injection protocols

A parameter and model technology, applied in the field of modeling of drug delivery and parameter generation of injection schemes, to achieve the effects of increased consistency, reduced image artifacts, and reduced number of retakes

Inactive Publication Date: 2016-09-21
BAYER HEALTHCARE LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also, because of certain mathematical limitations, the model may not be well oriented to each patient adaptation based on the test bolus augmentation

Method used

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  • Modeling of drug delivery and parameter generation of injection protocols
  • Modeling of drug delivery and parameter generation of injection protocols
  • Modeling of drug delivery and parameter generation of injection protocols

Examples

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Embodiment Construction

[0089] As used herein and in the appended claims, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. Thus, for example, a reference to "a parameter" includes a plurality of such parameters and their equivalents known to those skilled in the art, and so on, a reference to "the parameter" is a reference to one or more of such parameters. references to parameters and their equivalent parameters known to those skilled in the art, and so on.

[0090] In several representative embodiments, a physiologically based pharmacokinetic or PBPK modeling paradigm is used. In many embodiments, the PBPK model can eg be converted to the discrete time domain. Furthermore, many embodiments of the model will provide an explicit incorporation in the pharmacokinetics of transport delays (that is, transit times, eg, of contrast agents through the pulmonary vasculature). The distribution of drugs in the vascular structures throughout the b...

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Abstract

A system includes a parameter generation system for determining at least one parameter of an injection procedure (eg, an injection protocol parameter or an imaging system parameter), the parameter generation system including a physiology for modeling the delivery of a contrast agent injected into a patient A pharmacokinetic model based on: at least one nonlinear saturation term in the peripheral venous compartment, at least one constructible transport delay term across at least one compartment, or a volume for modeling blood Improvements in flow rate and its effect on contrast medium delivery after contrast injection has ceased. The physiologically based pharmacokinetic model may, for example, be discretizable.

Description

[0001] related application [0002] This application claims the benefit of U.S. Provisional Application Serial No. 61 / 358,400, filed June 24, 2010, and also contains subject matter that may be related to that disclosed and / or claimed in the following application: March 22, 2007 U.S. Patent Application No. 11 / 575,846 filed March 27, 2007, U.S. Patent Application No. 11 / 576,060 filed March 27, 2007 (now issued as U.S. Patent 7,925,330), U.S. Patent Application No. 12 / 519,040, filed June 12, 2009, U.S. Patent Application No. 12 / 519.213, filed June 15, 2009, and U.S. Patent Application No. 12 / 669,292, filed January 15, 2010, which The disclosure of is incorporated herein by reference and forms a part of this document. Background technique [0003] The following information is provided to assist the reader in understanding the techniques described below and some of the circumstances in which such techniques may be used. The terms used herein are not intended to be limited to any ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04
CPCA61M5/14A61M2205/17A61M2205/33A61M2205/50A61M2209/00A61B6/507G16H50/50A61K49/04
Inventor J·F·卡拉富特
Owner BAYER HEALTHCARE LLC
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