Method for preparing beta-amino acid

An amino acid and amino acid acylase technology, applied in the field of preparing beta-amino acids, can solve problems such as undeveloped, and achieve the effects of stable method, high optical purity and low cost

Inactive Publication Date: 2013-08-14
SUNCHEM SHANGHAI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the very high technical requirements, currently only a few large international companies such as the United States, Germany,

Method used

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  • Method for preparing beta-amino acid
  • Method for preparing beta-amino acid
  • Method for preparing beta-amino acid

Examples

Experimental program
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Embodiment Construction

[0027] Preferred embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0028] After N-acylation of amino acid, through enzymatic hydrolysis, the acyl group of one configuration of N-acylated β-amino acid is hydrolyzed to obtain the corresponding β-amino acid, while its corresponding configuration of N-acylated β-amino acid is not hydrolyzed , so as to separate by extraction according to the difference in the lipid-water solubility of the above substances; and then select another enzyme to hydrolyze the N-acylated β-amino acid in the corresponding configuration to obtain the corresponding amino acid, thereby obtaining a single configuration β-amino acid.

[0029] Specifically, β-amino acid acylase (β-Amino acylase) specifically hydrolyzes the amide group of (R) configuration N-acyl β-amino acids to generate free R-β-amino acids, while (S) configuration The amide group of the N-acyl β-amino acid is not hydrolyzed ...

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Abstract

The invention discloses a method for preparing beta-amino acid. The method comprises the following steps of: carrying out N acylation on amino acids, making acyl groups of N acylated beta-amino acids of one configuration to be hydrolyzed by enzymolysis to obtain corresponding beta-amino acids and not making N acylated beta-amino acids of a corresponding configuration to be hydrolyzed, separating the above amino acids according to their differences in fat water solubility properties by extraction, choosing another enzyme and hydrolyzing N acylated beta-amino acids of a corresponding configuration to obtain corresponding beta-amino acids, so as to obtain the beta-amino acid of a single configuration. The method provided by the invention is stable, environmentally friendly and safe, requires low cost, and has high optical purity. The invention also provides a new approach to producing optically-pure beta-amino acid.

Description

technical field [0001] The invention relates to the technical field of organic synthesis, in particular to a method for preparing β-amino acids. Background technique [0002] In recent ten years, β-amino acid has received great attention due to its important physiological activity and unique medicinal value. Certain functional β-amino acids are important components of many bioactive molecules, such as taxol, which is one of the anticancer drugs with phenylisoserine as the side chain. β-amino acids are usually found in humans, animals, microorganisms, marine animals and plants in free form or in the form of peptides, constituent parts of depsipeptides [1-3] . [0003] Studies have found that β-amino acids are important components of many natural medicines containing antibiotics, antifungal agents, cytotoxicity, and other pharmaceutical ingredients, and can be used to synthesize anti-cancer, AIDS, and blood pressure-lowering drugs. β-amino acid is the synthetic precursor of...

Claims

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Application Information

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IPC IPC(8): C12P13/04
Inventor 陆玉兵
Owner SUNCHEM SHANGHAI CO LTD
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