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Method for preparing beta-amino acid

An amino acid and amino acid acylase technology, applied in the field of preparing beta-amino acids, can solve problems such as undeveloped, and achieve the effects of stable method, high optical purity and low cost

Inactive Publication Date: 2013-08-14
SUNCHEM SHANGHAI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the very high technical requirements, currently only a few large international companies such as the United States, Germany, and the Netherlands have asymmetric catalytic hydrogenation methods, and this production process has not yet been developed in China

Method used

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  • Method for preparing beta-amino acid
  • Method for preparing beta-amino acid
  • Method for preparing beta-amino acid

Examples

Experimental program
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Embodiment Construction

[0027] Preferred embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0028] After N-acylation of amino acid, through enzymatic hydrolysis, the acyl group of one configuration of N-acylated β-amino acid is hydrolyzed to obtain the corresponding β-amino acid, while its corresponding configuration of N-acylated β-amino acid is not hydrolyzed , so as to separate by extraction according to the difference in the lipid-water solubility of the above substances; and then select another enzyme to hydrolyze the N-acylated β-amino acid in the corresponding configuration to obtain the corresponding amino acid, thereby obtaining a single configuration β-amino acid.

[0029] Specifically, β-amino acid acylase (β-Amino acylase) specifically hydrolyzes the amide group of (R) configuration N-acyl β-amino acids to generate free R-β-amino acids, while (S) configuration The amide group of the N-acyl β-amino acid is not hydrolyzed ...

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Abstract

The invention discloses a method for preparing beta-amino acid. The method comprises the following steps of: carrying out N acylation on amino acids, making acyl groups of N acylated beta-amino acids of one configuration to be hydrolyzed by enzymolysis to obtain corresponding beta-amino acids and not making N acylated beta-amino acids of a corresponding configuration to be hydrolyzed, separating the above amino acids according to their differences in fat water solubility properties by extraction, choosing another enzyme and hydrolyzing N acylated beta-amino acids of a corresponding configuration to obtain corresponding beta-amino acids, so as to obtain the beta-amino acid of a single configuration. The method provided by the invention is stable, environmentally friendly and safe, requires low cost, and has high optical purity. The invention also provides a new approach to producing optically-pure beta-amino acid.

Description

technical field [0001] The invention relates to the technical field of organic synthesis, in particular to a method for preparing β-amino acids. Background technique [0002] In recent ten years, β-amino acid has received great attention due to its important physiological activity and unique medicinal value. Certain functional β-amino acids are important components of many bioactive molecules, such as taxol, which is one of the anticancer drugs with phenylisoserine as the side chain. β-amino acids are usually found in humans, animals, microorganisms, marine animals and plants in free form or in the form of peptides, constituent parts of depsipeptides [1-3] . [0003] Studies have found that β-amino acids are important components of many natural medicines containing antibiotics, antifungal agents, cytotoxicity, and other pharmaceutical ingredients, and can be used to synthesize anti-cancer, AIDS, and blood pressure-lowering drugs. β-amino acid is the synthetic precursor of...

Claims

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Application Information

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IPC IPC(8): C12P13/04
Inventor 陆玉兵
Owner SUNCHEM SHANGHAI CO LTD
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