Use of S1P receptor conditioning agent on preventing and curing intestinal radiation sickness and radiation enteritis

A receptor modulator, individual technology, used in the prevention and/or treatment of gastrointestinal tissue damage caused by ionizing radiation, in the field of radiation enteritis

Active Publication Date: 2013-08-21
中国人民解放军军事科学院军事医学研究院辐射医学研究所
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  • Abstract
  • Description
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The present inventi

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  • Use of S1P receptor conditioning agent on preventing and curing intestinal radiation sickness and radiation enteritis
  • Use of S1P receptor conditioning agent on preventing and curing intestinal radiation sickness and radiation enteritis
  • Use of S1P receptor conditioning agent on preventing and curing intestinal radiation sickness and radiation enteritis

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Embodiment Construction

[0163] This specification discloses methods for preventing and / or treating intestinal type radiation sickness.

[0164] Groups in need include those who may be about to be exposed to radiation, such as a nuclear weapon attack, a nuclear dirty bomb terrorist attack, or are about to enter a radioactively contaminated area, and receive an effective amount of S1P receptor modulation several hours or at least 1 day before (possible) radiation exposure preventive treatment.

[0165] Individuals in need also include wounded or accident patients who have received radiation doses that may cause gastrointestinal damage, and receive effective doses of S1P receptor modulators immediately, several hours or at least 7 days after exposure.

[0166] The specification also discloses a method of treating enteritis caused by radiation therapy.

[0167] Radiation therapy and radiotherapy are used interchangeably herein and include external irradiation and internal irradiation, also referred to a...

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Abstract

The invention relates to a method of using an S1P receptor conditioning agent to prevent and/or cure stomach and intestine organization damages caused by ionising radiation, concretely to individually use, or combined with other treatment methods, the S1P receptor conditioning agent to prevent and/or cure intestinal radiation sickness and radiation enteritis caused by tumour radiation treatment.

Description

Technical field: [0001] The present invention relates to a method for preventing and / or treating gastrointestinal tissue damage caused by ionizing radiation using S1P receptor modulators. More specifically, the present invention relates to the use of S1P receptor modulators alone or in combination with other therapeutic methods to prevent and / or treat intestinal radiation sickness and radiation enteritis caused by tumor radiation therapy. Background of the invention: [0002] Acute radiation injury refers to a systemic disease caused by the body being exposed to a large dose (>1Gy) of ionizing radiation in a short period of time, known as acute radiation sickness (Acute Radiation Sickness, ARS), or collectively known as acute radiation injury syndrome (Acute Radiation Syndrome disease) , ARS). Nuclear terrorist attacks and large-scale nuclear accidents can produce a large number of patients with acute radiation sickness. According to the different damaged organs, acute ...

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Application Information

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IPC IPC(8): A61K45/00A61K31/137A61P1/00
Inventor 丛玉文丛悦柳晓兰张刘珍余祖胤赵振虎许倩
Owner 中国人民解放军军事科学院军事医学研究院辐射医学研究所
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