Application of costus lactone and derivative thereof in preparation of medicine for preventing and/or treating intestinal injury

A technology of medicine and use, which is applied in the field of preparation of woody lactone and its derivatives for the prevention and/or treatment of intestinal injury, and can solve problems such as the use of woody lactone that has not yet been seen, achieve good application prospects, and prolong survival rate and quality of life, and the effect of prevention and/or treatment of bowel injury

Pending Publication Date: 2022-02-25
成都医学院第一附属医院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no use of xylolide in the preparation of dr...

Method used

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  • Application of costus lactone and derivative thereof in preparation of medicine for preventing and/or treating intestinal injury
  • Application of costus lactone and derivative thereof in preparation of medicine for preventing and/or treating intestinal injury
  • Application of costus lactone and derivative thereof in preparation of medicine for preventing and/or treating intestinal injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1. Cosmolide reduces radiation-induced intestinal epithelial cell damage and inflammatory response

[0035] 1. Experimental method

[0036] Radiation treatment was used to simulate radiation intestinal injury. Normal human intestinal epithelial cells (HIEC cells) in the logarithmic growth phase were pre-treated with different concentrations (2.5 μM, 5 μM and 10 μM) of woody lactone (MCL) to culture the HIEC cells for 2 hours. Then the HIEC cells in each group were irradiated with a radiation dose rate of 2.166Gy / min and a total dose of 10Gy (PXI X-RAD 225, Precision X ray Inc., Branford, CT, USA). After radiation treatment, the HIEC cells in each group were co-cultured with the pretreatment concentration of woody lactone again for 48 hours.

[0037] After 48 hours, the cell viability of each group was measured with a CCK-8 detection kit, and the LDH release amount of cells in each group was measured with a CytoTox 96 kit. The cell culture supernatants of each...

Embodiment 2

[0042] Example 2, woody lactone alleviates radiation-induced intestinal toxicity and inflammatory response in mice

[0043] 1. Experimental method

[0044] The effect of columlide on the survival of wild-type C57BL / 6 mice irradiated with a radiation dose of 10 Gy was tested. Wild-type C57BL / 6 mice were randomly divided into 4 groups, namely:

[0045] Blank control group (Con): wild-type mice, neither receiving any treatment nor radiation, n=10;

[0046] Model control group (IR): wild-type mice were exposed to radiation, the radiation dose rate was 2.166Gy / min, and the total dose was 10Gy (PXI X-RAD 225, Precision X ray Inc., Branford, CT, USA). Accept woody lactone treatment, n=10;

[0047] MCL group: Wild-type mice were treated with xylolide at a dose of 50 mg / kg, intraperitoneally injected every day for 5 days, but not irradiated, n=10;

[0048] IR+MCL group: wild-type mice were pretreated with xylolide for 2 hours, and the dose was 50 mg / kg, and the drug was injected intr...

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Abstract

The invention provides application of costus lactone and a derivative thereof in preparation of a medicine for preventing and/or treating intestinal injury, and belongs to the technical field of chemical medicines. Specifically, the invention provides application of a compound shown as a formula I, or a salt thereof, or a stereoisomer thereof, or a solvate thereof, or a hydrate thereof, or a prodrug thereof in preparation of a medicine for preventing and/or treating intestinal injury, and R1 and R2 are respectively and independently selected from C1-C8 alkyl groups. Research finds that costus lactone has a protective effect on intestinal epithelial cell injury, especially radiation-induced intestinal epithelial cell injury, can effectively prevent and/or treat intestinal injury, especially radiation intestinal injury, especially radiation enteritis, can prolong the survival rate and improve the life quality of a patient, and has good safety within an effective dose. The costus lactone can be used for preparing medicines for preventing and/or treating intestinal injury, especially radioactive intestinal injury, and has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of chemistry and medicine, and in particular relates to the use of xylolide and its derivatives in the preparation of medicines for preventing and / or treating intestinal damage. Background technique [0002] Currently, radiotherapy remains an important treatment modality for various malignancies such as lung cancer, prostate cancer and renal cell carcinoma. With the development of radiation physics and technology, radiotherapy has made great progress in "physical precision", but the "physical precision" method still cannot completely solve the problem of radiation's toxic effect on normal tissues. During radiotherapy for intra-abdominal or pelvic malignant tumors, the radiation field will inevitably include healthy intestines. Since the small intestine is one of the highly radiosensitive organs, about 60% to 80% of patients who receive intra-abdominal or pelvic radiotherapy % will have symptoms of acute gas...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P1/00A61P29/00
CPCA61K31/365A61P1/00A61P29/00
Inventor 许颖常晓松吴东明李静刘腾
Owner 成都医学院第一附属医院
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