Ophthalmic composition for contact lens
A technology for contact lenses and compositions, which is applied in the field of inhibiting bacteria from attaching to contact lenses and lipids from attaching to contact lenses, can solve the problems of not finding polyoxyethylene castor oil or terpenoids, not finding them, and reducing bacteria. The risk of infection, the effect of suppressing discomfort, and reducing the risk of infection
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experiment example 1
[0141] Experimental example 1: Measurement of bacterial adhesion to contact lenses (1)
[0142] Experimental liquids (Examples 1-1 and 1-2, and Comparative Examples 1-1 to 1-4) having the formulations shown in Table 1 were prepared by a standard method, and these liquids were used to evaluate bacteria (Pseudomonas aeruginosa (ATCC9027)) Adhesion to soft contact lenses (SCLs) (SCL classification according to the US Food and Drug Administration: Group IV; main material: "etafilcon A"). When preparing the test liquid, borax was added in such an amount that the pH of each test liquid became 7 (the same applies hereinafter).
[0143] Each lens was immersed in 5 mL of sterilized physiological saline for 4 hours or more (lens pretreatment). 1 mL of each test solution was individually placed in a single well of a 24-well multi-well plate. Water on the surface of each lens was allowed to drain gently at the edge of the plate and the lens was placed in each well. Physiological sali...
experiment example 2
[0151] Experimental Example 2: Experiment for Measuring Bacterial Adhesion to Contact Lenses (2)
[0152]In the same manner as in Experimental Example 1, the experimental liquids shown in Table 1 (Comparative Example 1-1) and Table 2 (Examples 1-3 and 1-4 and Comparative Examples 1-5 and 1-6) were used Experiments measuring bacterial attachment were performed. The bacterial attachment inhibition rate (%) relative to the attached cell count obtained using the test liquid of Comparative Example 1-1 (control) was calculated.
[0153] Table 2 shows the results obtained. Camphor alone (Comparative Example 1-4) or borneol alone (Comparative Example 1-5) showed little bacterial attachment inhibitory effect, or showed a much lower bacterial attachment inhibitory rate, compared to the control (Comparative Example 1-1). (increased bacterial attachment). In contrast, the combined use of polyoxyethylene castor oil and camphor or borneol (Examples 1-3 or 1-4) unexpectedly exhibited an...
experiment example 3
[0165] Experimental Example 3: Experiment of Measuring Lipid Adsorption to PMMA (1)
[0166] Using the test liquids shown in Table 4 (Examples 2-1 and 2-2 and Comparative Examples 2-1 to 2-4), lipid adsorption to hard contact lenses was evaluated. As the hard contact lens, a flake obtained by uniformly cutting polymethylmethacrylate (PMMA) resin as a material of the hard contact lens into a circular shape was used.
[0167] 1,000 μL of each experimental solution (Examples 2-1 and 2-2 and Comparative Examples 2-1 to 2-4) were placed individually in each well of a 24-well microplate, and PMMA small pieces were impregnated in each well, followed by 34 Shake for 24 hours at °C. After shaking is complete, each PMMA pellet is rinsed in approximately 200 mL of normal saline and transferred to a 24-well microplate containing 1,000 μL of fluorescent lipid solution per well. Then, shaking was performed again at 34°C for 24 hours. After 24 hours, the shaking-treated PMMA was transfe...
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