Biphysic tissue engineering joint scaffold as well as preparation method and application thereof

A tissue engineering and joint technology, applied in the field of tissue engineering joint biphasic scaffold and its preparation, can solve the problem of no breakthrough progress in tissue engineering joint regeneration, and achieve good integration effect.

Inactive Publication Date: 2013-09-11
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Problems solved by technology

But so far, there has been no breakthrough in the regeneration of tissue-engineered joints

Method used

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  • Biphysic tissue engineering joint scaffold as well as preparation method and application thereof
  • Biphysic tissue engineering joint scaffold as well as preparation method and application thereof
  • Biphysic tissue engineering joint scaffold as well as preparation method and application thereof

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Experimental program
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Embodiment

[0054] 1. Materials and Methods

[0055] 1.1 Overall experimental design

[0056] Twenty 8-week-old nude mice (Shanghai Experimental Animal Center, Chinese Academy of Sciences) were randomly divided into two groups: the experimental group (n=10), and the control group (n=10); Normal control group (n=10). In the experimental group, the cell-scaffold compound was subcutaneously implanted on the back of nude mice, and in the control group, a scaffold without composite cells was subcutaneously implanted on the back of nude mice. All animal experiments strictly complied with the management regulations on the use of experimental animals of Shanghai Jiaotong University School of Medicine and obtained consent. For the overall experimental design, see figure 1 .

[0057] 1.2 Material Characterization

[0058] As the PLA content increased from 0% to 30%, the compressive modulus of polyglycolic acid / polylactic acid (PGA / PLA) scaffolds gradually increased, whereas the chondrocyte se...

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Abstract

The invention relates to a biphysic tissue engineering joint scaffold as well as a preparation method and an application thereof. The biphysic tissue engineering joint scaffold consists of a phrenology scaffold and a cartilage scaffold, wherein the cartilage scaffold is a PGA/PLA scaffold; the phrenology scaffold is a PCL/HA scaffold. The invention also provides a biphysic cell-tissue engineering joint scaffold constructor as well as a preparation method and an application thereof. The biphysic tissue engineering joint scaffold as well as the preparation method and the application thereof have the advantages that the biphysic tissue engineering joint scaffold is manufactured by utilizing a CAD/CAM technology, the external form and interior structure are accurate and controllable, the phrenology and the cartilage are matched with each other, the biphysic cell-tissue engineering joint scaffold constructor is formed by compositing seed cells by utilizing a tissue engineering technology, the tissue engineering joint can be regenerated in vivo and has the biological and mechanical biomechanical characteristics of the normal joint, an interface of a regenerated bones and the cartilage is well integrated, and the possibility is provided for performing biological reconstruction through the tissue engineering joint instead of the existing artificial joint.

Description

technical field [0001] The invention relates to the technical field of tissue engineering, in particular to a biphasic support for tissue engineering joints and its preparation method and application. This biphasic scaffold is composed of a bone-phase scaffold and a cartilage-phase scaffold, which are used to build bone and articular cartilage respectively, and the two are completely matched. Background technique [0002] Various joint trauma, inflammation, tumor and other diseases affect the lives of hundreds of millions of people in the world, and with the aging of the population and the development of urban construction and transportation, this number will increase year by year. The treatment of the advanced stage of these diseases is mainly artificial joint replacement surgery, which is a non-biological treatment. At present, the materials used in artificial joints are mainly metals, bioceramics and ultra-high molecular polyethylene. During the use of joints, mechanical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/48A61L27/46A61L27/18A61L27/12A61L27/38
CPCA61L27/38A61L27/26A61L27/3847A61L27/3852A61L27/46A61L27/56C08L67/04
Inventor 丁春明戴尅戎
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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