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This invention discloses a sublingual microcirculation imaging system with pressure detection and feedback control. The system comprises a shell, handle, inner support, focusing ring, circuit board, image sensor, probe, pressure sensor, and integrated unit. The integrated unit adjusts the focusing ring to control the probe movement based on the clarity of the sublingual microcirculation video and pressure information, until the video is stable and clear and the pressure reaches the target pressure value or a preset pressure range. This invention achieves real-time, accurate measurement and digital display of the probe-mucosal contact pressure in sublingual microcirculation imaging, enabling medical personnel of varying experience levels to quickly master and apply appropriate pressure, ensuring the standardization and repeatability of the examination.