Preparation method of 2-azyl-5-bromopyrimidine

A technology of aminopyrimidine and bromopyrimidine, which is applied in the field of preparation of 2-amino-5-bromopyrimidine, can solve the problems of complicated operation, polluted environment, expensive raw materials, etc., and achieves the effects of high chemical yield, convenient purification and simple operation.

Inactive Publication Date: 2013-09-11
安徽世华化工有限公司
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0002] In the process of synthesizing 2-amino-5-bromopyrimidine, the yield is low and the pollution is high. These synthetic methods have problems such as complicated operation, expensive raw materials, polluting the environment, and low yield.

Method used

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  • Preparation method of 2-azyl-5-bromopyrimidine
  • Preparation method of 2-azyl-5-bromopyrimidine
  • Preparation method of 2-azyl-5-bromopyrimidine

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Embodiment 1

[0019] A preparation method of 2-amino-5-bromopyrimidine, which is characterized in that 2-aminopyrimidine and N-bromosuccinimide are used as raw materials, soft water and acetonitrile are used as solvents, and finally prepared by bromination reaction 2-amino-5-bromopyrimidine, the reaction formula is as follows:

[0020]

[0021] The preparation method of a kind of 2-amino-5-bromopyrimidine is characterized in that it specifically comprises the following steps:

[0022] (1) Add 300ml of soft water and 50ml of acetonitrile to a 500ml three-necked reaction flask, and add 15g of 2-aminopyrimidine under stirring;

[0023] (2) Turn on the heating device of the three-necked reaction flask, raise the temperature to 70°C, and stir for 15 minutes.

[0024] (3) Inject 5ml of N-dimethylformamide with a disposable syringe.

[0025] (4) Slowly add 35 grams of N-bromosuccinimide into the three-necked reaction flask three times under stirring. A large amount of white solids precipitate...

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Abstract

The invention provides a preparation method of 2-azyl-5-bromopyrimidine. The 2-azyl-5-bromopyrimidine is prepared by serving 2-aminopyrimidine and N-bromo-succinimide as raw materials, brominating the raw materials and reacting in the presence of a catalyst N-dimethylformamide. The synthesis method provided by the invention is moderate in reaction conditions, simple and convenient to operate, convenient to purify, high in chemical yield and low in cost, thereby being suitable for synthesis methods of pyrimidine compounds in industrial production.

Description

technical field [0001] The invention relates to a synthesis method of pyrimidine heterocyclic compounds, in particular to a preparation method of 2-amino-5-bromopyrimidine. Background technique [0002] In the research on the process of synthesizing 2-amino-5-bromopyrimidine, the yield is low and the pollution is high. These synthetic methods have problems such as complicated operation, expensive raw materials, polluting the environment, and low yield. [0003] The invention is a pyrimidine compound synthesized under the condition of catalyst N-bromosuccinimide as a raw material, and pyrimidine is an important organic spiro compound. The raw materials selected in the present invention are easy to obtain, the catalyst and reaction solvent are cheap, and the reaction conditions are mild; the post-reaction treatment process is simple and easy to operate; the chemical yield is relatively high, and the pyrimidine heterocycle is synthesized. Contents of the invention [0004] T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/42
Inventor 孔祥俊贾邦乐马家松孔令航孔晓伟
Owner 安徽世华化工有限公司
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