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Inverted sugar electrolyte injection and preparation method thereof

A technology of electrolyte injection and invert sugar, which is applied in the direction of pharmaceutical formulations, active ingredients of phosphorus compounds, medical preparations containing active ingredients, etc., can solve the problems of complicated clinical use, inaccurate dosage, waste of medicines, etc., and achieve large clinical applications value, avoiding secondary pollution, and maintaining balance

Inactive Publication Date: 2013-09-18
YANGZIJIANG PHARMA GROUP SHANGHAI HAINI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The products currently used in the market are mainly invert sugar or invert sugar and sodium chloride preparations. The clinical use is more complicated, requiring medical staff to accurately calculate the preparations containing sodium, potassium, magnesium, and phosphorus, and then dilute and dissolve them into it. , so it is easy to cause the chance of secondary pollution, and it will also have the consequences of inaccurate dosage and waste of medicines

Method used

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  • Inverted sugar electrolyte injection and preparation method thereof
  • Inverted sugar electrolyte injection and preparation method thereof
  • Inverted sugar electrolyte injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0027] (1) Concentrated

[0028] Weigh 234g of sodium chloride, 8kg of glucose, 8kg of fructose, 300g of potassium chloride, 46g of magnesium chloride, 120g of sodium dihydrogen phosphate, 448g of sodium lactate, add 32g of concentrated hydrochloric acid, add 200L of 70°C water for injection to dissolve, pump into the concentrated tank, Add water to 320L.

[0029] (2) Depyrogenation

[0030] Add 600 g of activated carbon for needles in an amount of 0.15% (W / V), circulate for 30 minutes, and fine filter (membrane pores 0.22 μm) to remove carbon;

[0031] (3) dilution

[0032] Pump the concentrated dosing solution into the dosing tank, add water for injection to dilute to 400L, circulate for 30min, and fine filter (membrane pores 0.22μm);

[0033] (4) Filling

[0034] After the fine filtrate is checked for clarity, it is filled into a multi-layer co-extruded soft bag for infusion, 500ml / bag;

[0035] (5) Sterilization

[0036] After filling, place at 115°C and sterilize fo...

example 2

[0039] (1) Concentrated

[0040] Weigh 195g of sodium chloride, 7.2kg of glucose, 7.2kg of fructose, 270g of potassium chloride, 40g of magnesium chloride, 100g of sodium dihydrogen phosphate, 400g of sodium lactate, add 32g of concentrated hydrochloric acid, add 200L of 70°C water for injection to dissolve, and pump into the concentrated tank , add water to 320L.

[0041] (2) Depyrogenation

[0042] Add 600 g of activated carbon for needles in an amount of 0.15% (W / V), circulate for 30 minutes, and fine filter (membrane pores 0.22 μm) to remove carbon;

[0043] (3) dilution

[0044] Pump the concentrated dosing solution into the dosing tank, add water for injection to dilute to 400L, circulate for 30min, and fine filter (membrane pores 0.22μm);

[0045] (4) Filling

[0046] After the fine filtrate is checked for clarity, it is filled into a multi-layer co-extruded soft bag for infusion, 500ml / bag;

[0047] (5) Sterilization

[0048] After filling, place at 115°C and ste...

example 3

[0051] (1) Concentrated

[0052] Weigh 160g of sodium chloride, 6.4kg of glucose, 6.4kg of fructose, 240g of potassium chloride, 35g of magnesium chloride, 80g of sodium dihydrogen phosphate, 340g of sodium lactate, add 32g of concentrated hydrochloric acid, add 200L of 70°C water for injection to dissolve, and pump into the concentrated tank , add water to 320L.

[0053] (2) Depyrogenation

[0054] Add 600 g of activated carbon for needles in an amount of 0.15% (W / V), circulate for 30 minutes, and fine filter (membrane pores 0.22 μm) to remove carbon;

[0055] (3) dilution

[0056] Pump the concentrated dosing solution into the dosing tank, add water for injection to dilute to 400L, circulate for 30min, and fine filter (membrane pores 0.22μm);

[0057] (4) Filling

[0058] After the fine filtrate is checked for clarity, it is filled into a multi-layer co-extruded soft bag for infusion, 500ml / bag;

[0059] (5) Sterilization

[0060] After filling, place at 115°C and ster...

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PUM

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Abstract

The invention provides inverted sugar electrolyte injection. 1000ml of inverted sugar electrolyte injection comprises the following components by weight: 25-50g of glucose, 25-50g of fructose, 0.73-1.46g of sodium chloride, 0.93-1.86g of potassium chloride, 1.40-2.80g of sodium lactate, 0.375-0.75g of sodium dihydrogen phosphate, and 0.143-0.286g of magnesium chloride. Total parenteral nutritional injection is compounded of electrolyte and inverted sugar; a plurality of electrolytes, glucose and fructose can be simultaneously provided for an organism; and the targets of supplying body liquid to the organism, maintaining water and electrolyte balance and supplying energy are achieved; fussy preparation is reduced; secondary pollution is avoided; and the inverted sugar electrolyte injection has greater clinical application value. The invention provides a preparation method, which is suitable for industrial production.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to an injection and a preparation method thereof, in particular to an invert sugar electrolyte injection and a preparation method thereof. Background technique [0002] The function of Invert Sugar Electrolyte Injection is to replenish body fluids, electrolytes and heat energy, and is used for insufficiency of food or loss of a large amount of body fluids caused by various reasons. The invert sugar is usually glucose or fructose. Clinically, when patients cannot obtain nutrition through oral intake, total parental nutrition (TPN) becomes a necessary means for long-term survival of patients. The indications for Invert Sugar Electrolyte Injection include patients who cannot take oral nutrition or have insufficient nutritional support during the disease process, such as: (1) unable to take food normally from the gastrointestinal tract: gastrointestinal fistula; esophageal cancer, gastri...

Claims

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Application Information

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IPC IPC(8): A61K33/42A61K9/08A61P3/12A61P3/02A61K33/14A61K33/06A61K31/7004A61K31/191
Inventor 梁晓晖苏晓飞郑凤庚冯志祥
Owner YANGZIJIANG PHARMA GROUP SHANGHAI HAINI PHARMA