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Novel use of Polyflavanostilbene A in preparation of drugs for treating hemorrhagic fever with renal syndrome

A technology for renal syndrome and hemorrhagic fever, applied in the field of compounds, can solve problems such as uncertain effects

Inactive Publication Date: 2013-10-23
郭维 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antiviral treatments such as ribavirin and interferon are often used clinically, but the effect is not yet certain

Method used

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  • Novel use of Polyflavanostilbene A in preparation of drugs for treating hemorrhagic fever with renal syndrome
  • Novel use of Polyflavanostilbene A in preparation of drugs for treating hemorrhagic fever with renal syndrome
  • Novel use of Polyflavanostilbene A in preparation of drugs for treating hemorrhagic fever with renal syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of the compound Polyflavanostilbene A tablet involved in the present invention:

[0014] Take 5 grams of compound Polyflavanostilbene A, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0015] Embodiment 2: the preparation of the compound Polyflavanostilbene A capsules involved in the present invention:

[0016] Get 5 grams of compound Polyflavanostilbene A, add 195 grams of starch, mix well, pack into capsules and make 1000 capsules.

[0017] The following pharmacodynamic experiments will further illustrate its drug activity.

[0018] Experimental Study of Polyflavanostilbene A Against Hemorrhagic Fever Virus with Renal Syndrome

[0019] (1) In vitro inhibition experiment of hemorrhagic fever with renal syndrome virus

[0020] 1 material

[0021] (1) Virus strain: the international standard strain of hemorrhagic fever with renal syndrome virus 76-118, which is preserved by the Institute of Chinese Academy of Preventive Medicine. The virus containing 100 virus infectious titers per milliliter (100 TCID50 / ml) was used for the experiment.

[0022] (2) Cells: E6 clone line passaged by African green monkey kidney Vero, 139-141 passages. It contains 3% calf s...

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Abstract

The invention discloses a novel use of Polyflavanostilbene A in preparation of drugs for treating hemorrhagic fever with renal syndrome. Hemorrhagic fever with renal syndrome virus in-vivo and in-vitro inhibition experiments prove that Polyflavanostilbene A has low cell toxicity, has effects of directly killing hemorrhagic fever with renal syndrome viruses and obviously inhibiting hemorrhagic fever with renal syndrome virus multiplication, has an obvious function of protecting a hamster infected by the hemorrhagic fever with renal syndrome viruses, delays disease time, prolongs a course of the disease and reduces a death rate. Therefore, Polyflavanostilbene A is an effective and safe drug for treating hemorrhagic fever with renal syndrome.

Description

technical field [0001] The present invention relates to a new application of compound Polyflavanostilbene A, in particular to the application of Polyflavanostilbene A in the preparation of medicines for treating hemorrhagic fever with renal syndrome. Background technique [0002] There are 13 kinds of human viral hemorrhagic fever in the world. According to whether the disease has kidney damage, it is divided into two categories: with kidney damage and without kidney damage. In my country, it is mainly hemorrhagic fever with renal syndrome (HFRS), also known as epidemic hemorrhagic fever. Hemorrhagic fever (EHF); called Korean hemorrhagic fever (KHF) in North Korea; called hemorrhagic nephritis nephritis (HNN) in the Soviet Union; due to the establishment of specific serological diagnosis and the resolution of etiology, in 1982, the World Health Organization named it as renal syndrome Symptoms of hemorrhagic fever. [0003] The disease is caused by Korean hemorrhagic fever vi...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P31/14A61P13/12
Inventor 赵巧英
Owner 郭维
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