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Progressive stroke retardant

A blocker, stroke technology, applied in the direction of organic active ingredients, plant raw materials, peptide/protein ingredients, etc., can solve the problem of poor cerebral infarction effect, achieve anti-platelet aggregation, improve collateral circulation, and reduce blood fibrin concentration. Effect

Inactive Publication Date: 2013-10-23
童绥君
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Existing drug therapy, mainly anti-platelet aggregation therapy alone, has poor effect on progressive cerebral infarction

Method used

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  • Progressive stroke retardant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Hospital number 325027, patient Xu **, male, 61 years old, was admitted to the hospital (the First Affiliated Hospital of Xiamen University) with the main complaint of "right limb weakness for 1 day". History of present illness: due to sudden right limb weakness without obvious inducement 1 day before admission, the main manifestation is right limb weakness, which does not affect daily life, and can take care of oneself, no dizziness, headache, diplopia, visual rotation, no Nausea, vomiting, no hoarseness, dysphagia, no mental behavior abnormalities, the symptoms aggravated in the past 1 day, in order to further confirm the diagnosis and treatment, he went to our hospital, and the head MR showed "fresh infarct lesions in the left corona radiata area", and the diagnosis was planned "Cerebral infarction" received. Past history: There was a history of hypertension in the past, no systematic diagnosis and treatment, no regular monitoring of blood pressure changes. Admis...

Embodiment 2

[0027] 2. Hospital number: 468073. Patient Wu**, male, 67 years old, was admitted to the hospital with the main complaint of "choking on drinking water and slurred speech for 1 day". History of present illness: due to drinking water choking, dysphagia, slurred speech 1 day ago, manifested as unfluent speech, easy coughing when eating dry and hard food, choking coughing when drinking water, no obvious weakness and numbness of limbs, no dizziness, headache, no Coughing and expectoration, head MRI showed right pontine infarction, local stenosis of basilar artery, outpatient admission for "cerebral infarction". Diagnosed with "Grade 3 hypertension, very high risk" and "Type 2 diabetes" for many years. Admission examination: Body temperature: 36.5°C Pulse: 97 beats / min Respiration: 20 beats / min Blood pressure: 150 / 91mmHg. Clear mind, ambiguous speech, correct answers, normal function of higher cortex, bilateral pupils are equal in size, 2.5 mm in diameter, sensitive to light refle...

Embodiment 3

[0030]3. Hospital number: 466992, patient Shao **, female, 77 years old, was admitted to the hospital with the main complaint of "sudden left limb weakness for 7 hours". History of present illness: Sudden left limb weakness during activities 7 hours before admission, manifested as inability to lift the left upper limb and inability to stand in the left lower limb, accompanied by slurred speech, nausea, and non-projectile vomiting several times, and the symptoms reached a peak rapidly. And there was drowsiness, no dizziness, vomiting and other discomforts, so he came to our hospital for emergency treatment, and the head CT oral report showed that "the brain CT scan showed no obvious abnormalities, and the outpatient department planned to have "cerebral infarction" and was admitted to the hospital. Diagnosed with "type 2 diabetes", At present, insulin is used to control blood sugar, which has not been tested, and the details are unknown. Physical examination on admission: body te...

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Abstract

The invention discloses a progressive stroke retardant which is characterized in that the dosage per day comprises the following components of: 100-300mg of bayaspirin, 75-300mg of clopidogrel, 10-20mg of Lipitor, 5-20BU of batroxobin and 15-45 Danshen dropping pills. According to the provided progressive stroke retardant, multiple targets act on multiple progressive parts of stroke, and the progressive stroke retardant has obvious effects of stabilizing, preventing and breaking inflammatory response and pathogenic plaques of offending vessels, reducing the blood fibrin concentration, dilating blood vessels, improving collateral circulation and resisting platelet aggregation and has obvious effects on progressive diseases, disease outcome and prognosis of progressive stroke patients.

Description

technical field [0001] The present invention relates to a progressive stroke blocker. Background technique [0002] Patients with cerebral infarction often experience progressive aggravation of neurological deficits in the acute phase, and the incidence is reported in the literature to be about 16% to 43%. The occurrence of progressive stroke seriously affects the prognosis of patients. To date, understanding the pathogenesis, diagnostic predictors, and treatment of progressive stroke has been extremely challenging. [0003] Existing studies have shown that intracranial artery stenosis or occlusion (middle cerebral artery M1, basilar artery) is a high-risk factor for progressive stroke, and its possible mechanisms are as follows: ①The shedding of intracranial atherosclerotic plaques leads to new embolic events ; ② Blood vessel stenosis leads to hypoperfusion of blood flow, which in turn increases the ischemic penumbra, induces apoptosis and causes stroke progression, and is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61K36/537A61K31/4365A61K31/616A61K31/40A61P9/10
Inventor 童绥君马琪林毕敏李剑鹏江斌
Owner 童绥君
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