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Ion analyzer and ion analysis method

An ion analysis and ion detector technology, which is used in particle separation tubes, material analysis, material analysis by electromagnetic means, etc., can solve the problems of low efficiency and false positives, improve application ability, improve detection efficiency and accuracy Effect

Active Publication Date: 2016-12-21
SHIMADZU RES LAB SHANGHAI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] The technical problem to be solved by the present invention is to provide an ion analyzer using a differential ion mobility spectrometer array combined with a mass spectrometer array, and an ion analysis method using the ion detection device for fast and accurate sample analysis, for Solve the shortcomings of low efficiency and high false positives when using ion mobility spectrometry instruments for detection

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  • Ion analyzer and ion analysis method

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Embodiment 1

[0056] As mentioned earlier, when using a differential ion mobility spectrometer for ion detection, ions with different ion mobility are selected by changing the differential ion mobility spectrometer migration voltage. When it is desired to obtain a spectrum within the entire range of ion mobility, it is necessary to perform a step-by-step sweep of the analyzer's migration voltage. This process is usually very time-consuming. In order to achieve balance at each step, the time for one scan is usually several seconds to tens of seconds. To increase the efficiency of this analysis process, multiplex detection methods can be used. Figure 1A The structure in which the ion source is connected to the array of the flat panel differential ion mobility spectrometer is shown. Such as Figure 1A As shown, an ion source array 1 is connected to a flat-plate differential ion mobility spectrometry analyzer array (F-DMAA) 2, and ions extracted from the F-DMAA 2 can enter the next-stage flat-...

Embodiment 2

[0064] The basic principle of the ion analyzer in this embodiment is similar to that of Embodiment 1, but the difference is that in this embodiment, the Differential Mobility Spectrometer Analyzer Array (DMAA) and the Ion Trap Array (ITA) are both cylindrical, respectively referred to as C-DMAA 11 and C-ITA 13 are connected through a cylindrical ion transport channel array 12, such as Figure 2A shown. In this embodiment, each channel of the C-DMAA 11 has a centrosymmetric structure, and each channel is radially symmetrically distributed corresponding to the center line. Figure 2B Further showing the cross-sectional structure of C-ITA 13, the analysis units in the array are distributed in a complete circle around the same central axis, which can further focus the ions emitted from multiple analysis units in the array on the central axis of the device superior.

[0065] In addition, axial emission ion detectors can be set up at the outlets on the end cover of C-ITA 13 to det...

Embodiment 3

[0070] The basic principle of the ion analyzer in this embodiment is very similar to that in Embodiment 1, but the difference is that the mass analyzer array in this embodiment uses a quadrupole array. Such as image 3 As shown, each quadrupole in the planar quadrupole array (F-QA) 15 is connected to one F-DMAA unit in the F-DMAA 2 through a planar ion transport channel array 3 . Similar to the previous example, each unit of F-QA 15 can work in different modes according to the situation, and can be combined with different working modes of F-DMAA 2 to adapt to different application requirements. For example, when each channel of F-DMAA 2 works in synchronous mode, all units of F-QA 15 also work in synchronous mode, so as to increase the sensitivity when monitoring and confirming a certain ion. Alternatively, the different units of the F-QA 15 can be divided into groups so that ions of similar structure are monitored in different possible mass ranges. When each channel of F-DM...

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Abstract

The invention relates to an ion analyzer combined with a differential ion mobility spectrum analyzer array and a mass spectrometer array and an ion analysis method. The ion analyzer comprises an ion source or an array of ion sources, an array of differential ion mobility spectrometers, an array of ion transport channels, an array of mass spectrometers, and an array of ion detectors or an array of ion detectors connected in sequence. The differential ion mobility spectrometer array, the ion transport channel array, and the mass spectrometer array each include two or more channels, and the number of channels in these arrays is equal and corresponding to each other. In this ion analysis method, ions generated by an ion source or an ion source array are introduced into each channel of a differential ion mobility spectrometry analyzer array, and after selection based on ion mobility through each channel, the ion transport channel array enters the mass spectrometer array and Finally detected by ion detector or ion detector array.

Description

technical field [0001] The present invention relates to an ion separation and detection device and method, in particular to an ion analyzer and an ion analysis that use differential ion mobility spectrometer arrays and mass spectrometer arrays to efficiently separate and detect complex samples from chromatographic separation or direct sampling processes method. Background technique [0002] As countries around the world attach importance to public security and anti-terrorism capabilities, analytical instruments and methods that can quickly and accurately identify target compounds have increasingly become the research and development targets of various research institutions and instrument companies. As a relatively simple structure, low cost, but high speed and broad-spectrum ion analysis method, ion mobility spectrometer has played an important role in the anti-terrorism work of various countries. At present, instruments based on ion mobility spectrometers have been widely ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/00G01N27/62G01N27/622
CPCG01N27/624H01J49/009
Inventor 孙文剑蒋公羽
Owner SHIMADZU RES LAB SHANGHAI