Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method for taurine

A technology of taurine and sodium taurine, which is applied in the preparation of sulfonic acid, sulfonate, and organic compounds, etc., can solve problems such as consumption of a large amount of steam, waste of raw materials, low yield, etc., and solve environmental pollution. , The effect of reducing production cost and improving yield

Active Publication Date: 2013-11-06
QIANGJIANG YONGAN PHARMA
View PDF5 Cites 18 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there are also some disadvantages: ①The high-risk chemical raw materials such as liquid caustic soda and sulfuric acid are not only easy to corrode pipelines and equipment, but also easy to cause safety accidents during human operation, resulting in large economic losses; ②A large amount of sodium sulfate solid waste produce, wherein along with the long-term accumulation will take away part of the taurine, resulting in material loss, while sodium sulfate will always exist in the mother liquor, under the high temperature and high pressure synthesis conditions, it is very easy to block the cooler, heater, synthesis towers and high-pressure pipelines, resulting in the failure of normal production. At the same time, a large amount of sulfate solid waste increases labor intensity and is difficult to handle.
③In the subsequent extraction process, taurine (H 2 NCH 2 CH 2 SO 3 H) After multiple extractions, a large amount of waste mother liquor will be produced. ④ Part of the mother liquor has to be discharged, which not only causes waste of raw materials, low yield, but also pollutes the environment. At the same time, the concentration of mother liquor needs to consume a large amount of steam, making energy consumption higher

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method for taurine
  • Preparation method for taurine

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0023] A kind of preparation method of taurine provided by the embodiment of the present invention comprises the following steps: taking the sodium taurine solution into S 4+ After the pH value of the compound is adjusted, the crude taurine is separated by crystallization, and at the same time, the separated mother liquor is passed through ethylene oxide to convert it into sodium isethionate, and ammonia is added to react to regenerate sodium taurine.

[0024] In addition, taurine can also be produced through the following steps: take sodium taurine solution in S 4+ After the compound adjusts the pH value, continue to pass through ethylene oxide to generate a mixed solution of sodium isethionate and taurine, then separate the crude taurine, and then add ammonia to the mother liquor after separation to regenerate sodium taurine.

[0025] The reaction principle is as follows:

[0026]

[0027]

Embodiment 1

[0029] Take 500ml, 46% sodium taurine solution in the reaction flask, and slowly feed SO with stirring 2 Stop at pH 5.5, drop to normal temperature and filter to obtain the crude product of taurine, move the filtrate into the reaction flask, and slowly feed ethylene oxide (the amount of sodium taurate and ethylene oxide in the solution) at 72°C under stirring. The ratio of the amount of substance is 1: 1), until the reaction reaches the end point (determined with the number of iodine drops), then this reaction solution is supplemented with 1015g NH 3 ·H 2 O, heated to 250°C in a high-pressure reactor, with a pressure of 4.05 MPa, reacted for 1 hour, cooled down and discharged, evaporated to catch ammonia, and obtained sodium taurine solution. Taurine content was determined by HPLC, SO 3 2- Content and sodium isethionate content are determined by ion chromatography; The results are as follows, in mass percent:

[0030] Crude Taurine: Quantity: 243g

[0031] Taurine content...

Embodiment 2

[0037] Take 500ml, 46% sodium taurine solution in the reaction flask, and slowly feed SO with stirring 2 Stop at pH 5.5, then slowly feed ethylene oxide at 75°C (the ratio of sodium taurate to ethylene oxide in the solution is 1: 1.1), until the reaction reaches the end point (use iodine drop count Determine), down to normal temperature and filter to get the crude product of taurine, then add 1005g NH to this reaction solution 3 ·H 2 O, heated to 253°C in a high-pressure reactor, with a pressure of 4.1MPa, reacted for 1 hour, cooled down and discharged, evaporated to catch ammonia, and obtained sodium taurine solution. Result is as follows, by mass percent:

[0038] Crude Taurine: Quantity: 242g

[0039] Taurine content: 86.78%

[0040] SO 3 2- Content: 1.9%

[0041] Sodium taurine solution: Quantity: 616g

[0042] Sodium taurine content (folded taurine): 39.15%

[0043] Sodium isethionate content: 49.62%

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A disclosed preparation method for taurine comprises the following steps: employing an S<4+> compound for a sodium taurate solution to adjust pH value, then introducing oxirane to convert into a hydroxyethyl sulfonate, before or after introducing the oxirane, separating out a taurine crude product, adding ammonia into the hydroxyethyl sulfonate solution for a reaction to regenerate sodium taurate. By utilizing sodium balance in the system, the mother liquor is recycled in an addition reaction for regeneration of sodium taurate and further for synthesis and extraction of taurine. By fully utilizing the raw materials, the problem that high-danger chemical raw materials such as liquid alkali and concentrated sulfuric acid are used in a large amount in the conventional technology is solved, thus a large amount of a solid waste salt sodium sulfate is avoided to generate, also the environmental pollution problem caused by the taurine mother liquor which is subjected to multiple concentration and is discharged without good utilization in the conventional technology is solved, further vapor required in multiple concentration of the mother liquor is reduced, and therefore efficiency is improved and production cost is reduced.

Description

technical field [0001] The invention belongs to the technical field of organic chemical synthesis, and in particular relates to a preparation method of taurine. Background technique [0002] Taurine is a non-protein amino acid. As a drug, it has the effects of anti-inflammatory, antipyretic, analgesic, anti-convulsant and lowering blood pressure. It has a good effect on infant brain development, nerve conduction, visual function improvement and calcium absorption. , taurine has a series of unique functions on the cardiovascular system, can enhance physical fitness, relieve fatigue, so taurine is gradually widely used in medical, food and health care and other fields. [0003] Taurine can be prepared by biological extraction and chemical synthesis. The former is rarely used due to the influence of raw materials and cost; at present, ethanolamine esterification method and ethylene oxide method are mainly used in industrial production. Compared with ethanolamine esterification...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C309/14C07C303/22
CPCC07C303/32C07C303/18C07C303/22C07C309/14
Inventor 陈勇
Owner QIANGJIANG YONGAN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com