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Surface-modified rubber plug and preparation method thereof

A technology for surface modification and rubber stoppers, applied in the field of surface modified rubber stoppers and their preparation, can solve the problems of unreliable sealing performance and safety performance of rubber stoppers, difficult film covering process of rubber stoppers, increased production costs, etc., to achieve easy Implementation, obvious effect, effect of reducing difficulty and cost

Inactive Publication Date: 2013-11-27
SHANDONG WEIGAO GROUP MEDICAL POLYMER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1. The sealing performance and safety performance of the rubber plug are unreliable
[0007] 2. The rubber stopper coating process is difficult and costly
[0008] 3. Medical rubber stopper materials are mainly limited to butyl rubber and halogenated butyl rubber stoppers, which increases production costs

Method used

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  • Surface-modified rubber plug and preparation method thereof

Examples

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Effect test

preparation example Construction

[0030] The preparation method of the medical rubber stopper modified by PVDC of the present invention comprises the following steps:

[0031] Step 1: Provide the rubber plug body, which can be a molded or commercially available medical rubber plug;

[0032] Step 2, cleaning and drying the rubber stopper body;

[0033] Step 3, putting the cleaned and dried rubber stopper into a closed corona stirring tank for corona treatment for 20-120 minutes;

[0034] Step 4, put the corona-treated rubber plug into the PVDC emulsion at 60-120°C under nitrogen, and stir for 6-24 hours;

[0035] Step 5, the rubber stopper is taken out from the emulsion, washed with water, ethanol, and chloroform in sequence, and dried to obtain a surface-modified medical rubber stopper.

Embodiment 1

[0037] Clean and dry the commercially available halobutyl rubber stoppers, put them into a corona stirred tank, adjust the current intensity to 9A, treat with air corona plasma under normal pressure for 20 minutes, turn off the corona, and remove the rubber stoppers within two hours. Transfer to a PVDC emulsion at 70°C under nitrogen, stir for 6 hours, take the rubber plug out of the emulsion, wash and dry with water, ethanol, and chloroform in sequence to obtain a surface-modified rubber plug.

Embodiment 2

[0039] Use natural rubber stopper, current intensity 12A, normal pressure nitrogen plasma treatment for 60 minutes, 80°C PVDC emulsion, stirring for 16 hours, the rest is the same as Example 1.

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Abstract

The invention discloses a surface-modified rubber plug and a preparation method thereof. The rubber plug comprises a rubber plug body and a modification layer on the surface of the rubber plug body. The modification layer is modified through PVDC (polyvinyl dichloride) emulsion. Chemical modification is performed on the surface of the rubber plug by the aid of the corona-aided high polymer material surface modification technology, oxygen-blocking and dampness-blocking features of the PVDC is utilized to increase negative pressure maintaining capacity of a vacuum container, block the contact of the rubber plug body and medicines and blood, and increase safety and biocompatibility of the rubber plug. The method is suitable for the existing rubber plugs available on the market, thermoplastic elastomer rubber plugs and surface modification of sealing parts with complex shapes.

Description

technical field [0001] The invention relates to the technical field of medical rubber plugs, in particular to a surface-modified rubber plug and a preparation method thereof. Background technique [0002] The packaging materials and packaging forms of medicines, especially the packaging materials that are in direct contact with medicines, play an important role in ensuring the stability of medicines. Unsuitable packaging materials can cause the active ingredients of the drug to be adsorbed on the packaging material, or the ingredients in the packaging material can be adsorbed on the surface of the drug, or even a chemical reaction occurs between the packaging material and the drug, resulting in the failure of the drug, and sometimes even serious side effects . Traditionally commonly used butyl rubber and halogenated butyl rubber stoppers are better than natural rubber in terms of cleanliness, chemical stability, air tightness, and biological safety, but due to the complexit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J1/14A61J1/00C08J7/12C08J7/04C08L23/28C08L7/00C08L9/00C08L101/00C09D127/08C09D133/00
Inventor 刘向东殷敬华赵卫东
Owner SHANDONG WEIGAO GROUP MEDICAL POLYMER
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