Improved filter for removing substances from blood or from blood derivatives and method for obtaining said filter

A filter and derivative technology, applied in membrane filters, chemical instruments and methods, separation methods, etc., can solve the problems of low molecular weight, increased production cost, inappropriateness, etc., and achieve the effect of avoiding control instruments

Active Publication Date: 2015-08-26
GVS SPA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This leads to an increase in production costs and thus in the cost of the final product obtained
[0010] Another patent document WO2005 / 113136 describes a polyurethane material with an average molecular weight equal to or greater than 20,000 Da for leukocyte adsorption, and this prior art document states that it is inappropriate to use polyurethane with a molecular weight of Too low for leukocyte-depleted material

Method used

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  • Improved filter for removing substances from blood or from blood derivatives and method for obtaining said filter

Examples

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Embodiment 1

[0026] A dispersion of polyurethane in water with a molecular weight of 12 kDa to 18 kDa was used, with a polymer content of 5% by weight. The dispersion is obtained by dissolving the polyol and isocyanate components in a ketone solvent, then dispersing in water; and finally removing the solvent by distillation.

[0027] The polyurethane coating was applied to the PBT nonwoven fabric by dipping in the dispersion kept at ambient temperature, dried at 60°C, and after drying for 20 hours, it was washed in osmotized water at 50°C. Then dry at 60°C.

Embodiment 2

[0029] A dispersion of polyurethane in water with a molecular weight of 12 kDa to 18 kDa was used, which was obtained by diluting the polyurethane dispersion in water at ambient temperature with a PU content of 50% by weight and further adding water to reach Calculated as a polymer content of 0.5%.

[0030] The polyurethane is NORETHANEWB 8301 produced by NOVOTEX ITALIANA SPA.

[0031] The polyurethane coating was applied to the nonwoven fabric of PBT by dipping in the dispersion maintained at ambient temperature, dried at 50°C. After drying for 20 hours, it was washed in permeate water at 40°C. Then dry at 30°C.

Embodiment 3

[0033] A dispersion of polyurethane in water with a molecular weight of 12 kDa to 18 kDa was used, with a polymer content of 5% by weight.

[0034] The polyurethane coating was applied to the PBT nonwoven fabric by dipping.

[0035] Dry at 100°C.

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Abstract

A filter for removing substances, including leukocytes and platelets by way of non-limiting example, from whole blood or from blood derivatives, the filter includes a casing containing a layered filter element, at least one layer of this latter being coated with polyurethane; this polyurethane has a number average molecular weight between 10,000 and 20,000 Dalton. A method for forming the layered filter element for a filter such as mentioned above, in which at least one layer of this filter element is impregnated with polyurethane by immersing it in a container of a mixture in which the polyurethane is present. This mixture includes a solution in which the polyurethane is dissolved in a polar solvent such as water.

Description

technical field [0001] The invention relates to a filter for removing substances, such as in particular white blood cells and platelets, from blood or from blood derivatives. The invention also relates to a method for forming the filter described above. Background technique [0002] Filtration of blood components for transfusion is a known practice often performed on blood drawn from donors. The main purpose of this filtration or purification is to minimize the presence of leukocytes in the transfused blood (leukodepletion) and the presence of platelets in it, in order to reduce possible harmful effects associated with the transfusion, such as: heterologous immunity ; non-hemolytic febrile transfusion reaction prevention (non-hemolytic febrile transfusion reaction prevention); infection caused by cytomegalovirus; reduction of cytokine release, etc. [0003] Consequently, the use of filters for leukapheresis in the preparation of blood components has become common and, in f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/36B01D39/00
CPCB01D2239/065A61M1/3633B05D5/00B05D1/18B01D39/00B05D3/0209B01D2239/0478A61M1/341A61M1/3601A61M1/3615A61M1/3413A61M1/342
Inventor 马西莫·斯卡利亚里尼卢卡·奎尔泽
Owner GVS SPA
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