Heteroaryl phosphamide compounds with antiviral activity

A compound and hydrate technology, applied in the field of compounds for the treatment of flavivirus infection such as hepatitis C virus (HCV) infection, can solve the problems of not reducing the use of interferon and the mutation of hepatitis C virus

Inactive Publication Date: 2013-12-04
世方科技(杭州)有限公司
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  • Abstract
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Problems solved by technology

The introduction of these protease inhibitors was a major advance in hepatitis C treatment, but these drugs still have several disadvantages: the agents do not reduce the use of interferon and the virus can rapidly mutate and develop resistance
The

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  • Heteroaryl phosphamide compounds with antiviral activity
  • Heteroaryl phosphamide compounds with antiviral activity
  • Heteroaryl phosphamide compounds with antiviral activity

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[0025] Terms used herein are used in their accepted meanings. The following definitions are intended to clarify, but not limit, these terms.

[0026] Unless otherwise clearly stated in the context, the singular words "a", "and" and "the" used herein include plural referents.

[0027] The range of carbon atoms represented in this article, such as C 1 -C 12 The number of carbon atoms in an alkyl group shall include every number in that range, thus including all numbers of carbon atoms between 1 and 12 and other stated numbers of carbon atoms in said range; it will be further recognized that Within the scope of the present invention, sub-ranges within the specified range of carbon atoms may be individually included in smaller ranges of carbon atoms, and the present invention includes carbon atom numbers excluding one or several carbon atom numbers Ranges also include subranges excluding one or both limits of carbon atoms within the specified range of carbon atoms.

[0028] Th...

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Abstract

The invention discloses heteroaryl phosphamide compounds, which are used for curing or preventing hepatitis C virus infection or other virus infections. These compounds can be used as hepatitis C virus replication inhibitors, and can be used together with other therapeutic agents, especially other anti-virus drugs or preparations. The invention especially provides compounds, which are used as the hepatitis C virus replication inhibitors, drug components, which contain these compounds, and a usage method of these compounds to cure virus infection such as hepatitis C virus infection.

Description

technical field [0001] The present invention provides compounds useful in the treatment of flavivirus infections such as hepatitis C virus (HCV) infection. In particular, the present invention discusses compounds that are inhibitors of hepatitis C virus replication, pharmaceutical compositions containing such compounds and methods of using these compounds to treat hepatitis C virus infection. Background technique [0002] Hepatitis C virus (HCV) is a hepatropic flavivirus that is transmitted among people through direct blood contact (blood transfusion or contaminated needles) or through bodily fluids. After exposure to the virus, 15-25% of infected persons will experience symptoms of acute infection followed by a viral elimination phase, while the remaining 75-85% of infected persons will experience symptoms of chronic HCV infection. Chronic infection leads to inflammation and progressive liver damage evidenced by biopsy and elevated liver enzyme levels. Over 10 to 40 year...

Claims

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Application Information

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IPC IPC(8): C07H19/207A61K31/7076A61P31/14A61P1/16
Inventor 吴劲梓古德木德森·克里斯金
Owner 世方科技(杭州)有限公司
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