Displayable drug-loaded nano silver sodium alginate microsphere blood vessel embolic agent and preparation method thereof

A vascular embolic agent, sodium alginate technology, applied in X-ray contrast agent preparation, pharmaceutical formulations, anti-tumor drugs, etc., can solve the problem that sodium alginate microsphere vascular embolic agent does not have X-ray visibility, etc., to achieve Ease of follow-up observation, prevention of damage, high blood vessel targeting effect

Inactive Publication Date: 2013-12-11
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the technical problem that the existing drug-loaded sodium alginate microsphere vascular embolization

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0017] Embodiment 1: The drug-loadable nano-silver sodium alginate microsphere vascular embolism agent includes a carrier, a developable substance and an antitumor drug, the developable substance is nano-silver particles, and the antitumor drug is paclitaxel and etopol Glycoside or carboplatin, the sodium alginate encapsulates the nano-silver particles and antitumor drugs, the molar ratio of the sodium alginate to the nano-silver particles is 1-10:1, the weight of the sodium alginate and the anti-tumor drugs The ratio is 1-90:1.

specific Embodiment approach 2

[0018] Embodiment 2: This embodiment differs from Embodiment 1 in that the molar ratio of sodium alginate to silver nanoparticles is 2-8:1. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0019] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the molar ratio of sodium alginate to silver nanoparticles is 5:1. Others are different from the first or second specific embodiment.

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Abstract

The invention provides a displayable drug-loaded nano silver sodium alginate microsphere blood vessel embolic agent and a preparation method thereof, and relates to a blood vessel embolic agent and a preparation method thereof. An object of the invention is to solve the technical problems that a conventional drug-loaded sodium alginate microsphere blood vessel embolic agent has no X-ray visibility. The method comprises the steps of mixing a sodium alginate solution containing nano silver particles and an antineoplastic drug solution, mixing the above mixture with a solidifying liquid via a dropping method, and thus the displayable drug-loaded nano silver sodium alginate microsphere blood vessel embolic agent is obtained. The displayable drug-loaded nano silver sodium alginate microsphere blood vessel embolic agent has good visibility under X rays, is convenient for observing embolic degree, effectively prevents mistaken embolism, and at the same time, facilitates follow-up observation.

Description

technical field [0001] The invention relates to a blood vessel embolism agent and a preparation method thereof. Background technique [0002] Because interventional embolization can treat some lesions that are not suitable for direct surgery or difficult to perform surgery, it can be cured, or even radically cured. At the same time, it can replace some operations, simplify treatment, improve curative effect, and reduce surgical reactions. Interventional embolization is widely used in the treatment of massive bleeding, arteriovenous malformations, benign and malignant tumors and other diseases. Interventional embolization has become one of the main means of treating tumors in North America and Europe because of its less invasiveness, reliable curative effect, less side effects after surgery, and lower cost than traditional surgical treatment. Embolization material is the key factor to determine the success of interventional embolization. In view of the above reasons, in rec...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K49/04A61K31/734A61P35/00A61K31/337A61K31/7048A61K31/282
Inventor 李莉李兆清李珍郑卫郑玉峰
Owner HARBIN ENG UNIV
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