SGLT2 (Sodium-glucose co-transporter 2) inhibitor and use thereof

A technology of inhibitors and uses, applied in the field of type 2 Na+-glucose co-transporter inhibitors, can solve the problems of diarrhea, gene mutation, serious problems, etc.

Inactive Publication Date: 2013-12-18
CHINA PHARM UNIV
View PDF1 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, clinical studies have found that genetic mutations in SGLT1 can lead to severe or even fatal diarrhea

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • SGLT2 (Sodium-glucose co-transporter 2) inhibitor and use thereof
  • SGLT2 (Sodium-glucose co-transporter 2) inhibitor and use thereof
  • SGLT2 (Sodium-glucose co-transporter 2) inhibitor and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Experimental Study on Inhibitory Activity of Compounds 1 to 25 on SGLT2 and SGLT1

[0017] 1. Experimental materials: 96-well plate, Fetal bovine serum (FBS), Ham's F12 medium, Dimethyl sulfoxide (DMSO), Sodium assay buffer (140mM NaCl, 2mM KCl, 1mM CaCl 2 , 1mM MgCl 2 , 10mMN-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid [HEPES], 5mM tris-HCl, pH7.4), Choline assay buffer, 14 C-AMG, Nonlabeled AMG, Sodium dodecyl sulphate (SDS), MicroScint MS-40 (Packard Instrument Co., Meriden, Ct, USA), Top Count Microplate Scintillation Counter (Packard Instrument Co., Meriden, CT, USA).

[0018] 2. Experimental steps:

[0019] · Transfection of full-length cDNA clones expressing human SGLT1 and SGLT2 into Chinese Hamster Ovary (CHO) cells.

[0020] The transfected cells were cultured in Ham's F12 medium (3*10 per well) containing 10% fetal bovine serum (FBS). 4 cells) at 37°C, 5% CO 2 Incubate for 24 hours under conditions.

[0021] • Dimethyl sulfoxide (DMSO) dissolves c...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the field of medicinal chemistry, and particularly relates to compounds (1-25) and a medicinal use of a medicinal composition containing the compounds, in particular a use as an SGLT2 (Sodium-glucose co-transporter 2) inhibitor.

Description

technical field [0001] The present invention relates to the field of medicinal chemistry, in particular to 25 compounds and containing these compounds, pharmaceutical compositions and their medical uses, especially as type 2 Na + - Use of glucose cooperating transporter (SGLT2) inhibitors. Background technique [0002] The incidence of diabetes is increasing year by year. At present, there are about 285 million diabetic patients in the world, accounting for 6.4% of the world's population. It is expected that by 2030, this number will reach 438 million. Diabetes mellitus is a metabolic disease characterized by elevated blood sugar caused by insulin resistance and secretion defects in the human body. It is mainly divided into type I (T1DM) and type II (T2DM). The former is due to the inability of pancreatic β-cells to produce enough insulin (absolute insulin deficiency), which mostly occurs in adolescents; the latter is due to insufficient insulin secretion or insulin resista...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/704A61K31/7034A61K31/7032A61K31/34A61K31/343A61K31/404A61K31/443A61P3/10
Inventor 徐金星陆涛
Owner CHINA PHARM UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap