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Sweet wormwood thunder god vine medicine pair combination drug and preparation method and application thereof

A technology of Tripterygium wilfordii and Artemisia annua, applied in the field of combination of traditional Chinese medicines, can solve the problems of easy accumulation of toxicity, irreversible lesions of reproductive organs, etc., and achieve the effect of low toxicity and good activity

Active Publication Date: 2013-12-18
CHONGQING ACAD OF CHINESE MATERIA MEDICA +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the therapeutic dose of Tripterygium wilfordii is very close to the poisoning dose, and the long-term drug toxicity is easy to accumulate, causing irreversible lesions in reproductive organs, liver, kidney and other organs

Method used

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  • Sweet wormwood thunder god vine medicine pair combination drug and preparation method and application thereof
  • Sweet wormwood thunder god vine medicine pair combination drug and preparation method and application thereof
  • Sweet wormwood thunder god vine medicine pair combination drug and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 Investigation on the supercritical extraction process of Artemisia annua Tripterygium wilfordii drug

[0014] Weigh 5 parts of a mixture of 100.0g dried Artemisia annua and Tripterygium wilfordii (1:1), and use methanol, ethanol, 75% ethanol, ethylene glycol, and ethyl acetate as entrainers to extract one part without entrainment Agent as a control;

[0015] Fill the above-mentioned mixture of Artemisia annua and Tripterygium wilfordii into a supercritical extraction kettle, press the programmed temperature and increase pressure to carry out dynamic extraction, CO 2 Flow rate is 4.6L·h -1 , Extraction temperature 45℃, extraction pressure 25MPa, dosage of entrainer is 2mL·g -1 , The entrainer was pumped quantitatively, and the extraction time was 100min; the product was collected from the analysis kettle, the organic solvent was recovered under reduced pressure, and the supercritical extract of Tripterygium wilfordii was obtained. The specific results are shown in Ta...

Embodiment 2

[0020] Example 2 The effect of different extraction methods on the transfer rate of active ingredients

[0021] 1. Preparation of the alcohol extract of Tripterygium wilfordii in Artemisia annua

[0022] The mixture of Artemisia annua and Tripterygium wilfordii (1:1) was extracted twice with 95% ethanol, and the amount of ethanol was 8 times the amount of the medicinal materials. The extraction time was 2, 1.5 hours, boiling at 180°C, and keeping slightly boiling at 130°C. For 2, 1.5h. After extraction, pour out the medicine residue and let it dry. The two extracts were combined. The 95% ethanol extract was concentrated under reduced pressure at a temperature of 50°C, a rotation speed of 34r / min, and a pressure of -0.095MPa, and concentrated to 2L. Take out the 500mL reserve sample, evaporate it in a water bath at a temperature of 82.5°C, and then put it into an oven to dry it into a dry product (the temperature of the oven is 42.5°C) to obtain an alcohol extract of Tripterygium...

Embodiment 4

[0033] Example 4 Investigation of liver and kidney damage in mice

[0034] ICR mice, clean grade, male and female, weight 18-22g, a total of 180 mice, the mice were randomly divided into 9 groups, namely: blank control group; Tripterygium wilfordii Alcohol extract group; Tripterygium wilfordii Drug pair supercritical extract Ⅰ; Artemisia annua tripterygium wilfordii drug pair supercritical extract group Ⅱ; Artemisia annua wilfordii drug pair supercritical extract group Ⅲ; Artemisia annua, Tripterygium wilfordii drug pair supercritical extract group Ⅳ; Artemisia annua Rattan medicine pair supercritical extract group V, tripterygium wilfordii supercritical extract group and artemisia annua supercritical extract group. Each group of experimental animals was divided into two batches, each with 10 animals, half of the male and the female, one group was administered for 5 days, and one group was administered for 10 days. The administration dose is the clinically equivalent amount (18....

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PUM

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Abstract

The invention provides a sweet wormwood thunder god vine medicine pair combination drug. The sweet wormwood thunder god vine medicine pair combination drug is composed of a mixture or extractant of sweet wormwood and thunder god vine. The invention further provides the extractant of the sweet wormwood thunder god vine medicine pair combination drug. The extractant of the sweet wormwood thunder god vine medicine pair combination drug has lower toxicity for liver and kidney compared with the extractant of thunder god vine and has better activity for treating rheumatic arthritis compared with commercially available thunder god vine medicinal preparation.

Description

Technical field [0001] The invention relates to a combination of traditional Chinese medicine and medicine, and more specifically to a combination medicine of Artemisia annua and Tripterygium wilfordii, a preparation method and application. technical background [0002] Tripterygium wilfordii is mild in nature and bitter in taste. It has the effects of dispelling wind and dampness, relaxing muscles and collaterals, reducing swelling and pain, killing insects and detoxification. Modern research has found that it has anti-inflammatory, immunosuppressive, anti-fertility, anti-tumor, antibacterial, and analgesic activities. In recent years, it has been found that Tripterygium wilfordii has significant effects on organ transplant rejection, autoimmune diseases, nephrotic syndrome, cancer, etc. It is clinically used for rheumatoid arthritis, rheumatoid arthritis, bruises, and glomerulonephritis. , Lupus erythematosus, nephrotic syndrome and other intractable diseases. So far, schola...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/37A61P19/02A61P29/00
Inventor 杨大坚陈新滋吕爱平陈士林徐宏喜卞兆祥陈国庆张毅
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA
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