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A kind of livestock and poultry immune enhancer bursa polypeptide

An immune enhancer and bursal polypeptide technology, which is applied in the field of livestock and poultry immune enhancer bursal polypeptide, can solve the problems of high cost, no effective vaccine prevention and control of infectious diseases, and reduced vaccine protection.

Inactive Publication Date: 2015-11-18
南京吉升和化工科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional vaccines and new vaccines have also encountered some intractable problems: vaccines have low immunity to certain groups of people; repeated immunizations are required to produce better immunity; vaccine protection is prone to seriously decrease over time; There are no effective vaccines against infectious diseases
So far, many substances have been found to have immune adjuvant activity, but most of them have not been used in practice due to high cost or toxic side effects

Method used

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  • A kind of livestock and poultry immune enhancer bursa polypeptide
  • A kind of livestock and poultry immune enhancer bursa polypeptide
  • A kind of livestock and poultry immune enhancer bursa polypeptide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] ——BP14 as an immune enhancer for recombinant avian influenza virus inactivated vaccine (H5N1 subtype, Re-6 strain)

[0030] 1. Synthetic BP14

[0031] Entrust commercial peptide synthesis company according to COOH-G-H-K-T-R-N-D-P-L-K-G-A-V-D-NH 2 The amino acid sequence (sequence 1) synthesizes the polypeptide, and the purity is required to be ≥ 95%.

[0032] 2. Vaccines

[0033] The recombinant avian influenza virus inactivated vaccine (H5N1 subtype, Re-6 strain) is a commercial vaccine (manufacturer: Guangdong Yongshun Biopharmaceutical Co., Ltd., batch number: 2013037).

[0034] 3. Grouping of experimental animals

[0035] 40 SPF chickens were randomly divided into four groups, 10 in each group: (1) Recombinant avian influenza virus inactivated vaccine (H5N1 subtype, Re-6 strain) immunization group (each bird immunized with inactivated vaccine 1 part / 0.25 ml); (2) Inactivated vaccine + BP14 group (prepared aseptically according to the ratio of inactivated vaccine...

Embodiment 2

[0044] The polypeptide described in the present invention may also be a plurality of concatemers of the polypeptide described in Example 1, such as

[0045] COOH-G-H-K-T-R-N-D-P-L-K-G-A-V-D-G-H-K-T-R-N-D-P-L-K-G-A-V-D-NH 2 and (sequence 2)

[0046] COOH-G-H-K-T-R-N-D-P-L-K-G-A-V-D-G-H-K-T-R-N-D-P-L-K-G-A-V-D-G-H-K-T-R-N-D-P-L-K-G-A-V-D-NH 2 (Sequence 3).

Embodiment 3

[0048] In the vaccine production process of the livestock and poultry immune enhancer BP14 according to the present invention, according to the content of BP14 in the final product of the vaccine is 0.1 μg / feather ratio, it is added to the poultry vaccine antigen liquid and then formulated into a water phase, and then conventionally Mixed with oil phase to emulsify into poultry vaccine.

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Abstract

The invention relates to a livestock and poultry immune enhancer bursa fabricius polypeptide. The immune enhancer bursa fabricius polypeptide disclosed by the invention is a small molecular polypeptide. The immune enhancer disclosed by the invention has an extensive immune enhancing effect and has the effects of stimulating the proliferation of lymphocytes, regulating a cytokine and improving the immune efficacy of vaccines against a variety of livestock and poultry, and the amino acid sequence of the polypeptide is COOH-G-H-K-T-R-N-D-P-L-K-G-A-V-D-NH2.

Description

technical field [0001] The invention relates to a livestock and poultry immune enhancer bursa polypeptide, which belongs to the technical field of veterinary biological products. Background technique [0002] Vaccine immunization is generally considered to be one of the most effective and economical means to prevent and control livestock and poultry infectious diseases. However, traditional vaccines and new vaccines have also encountered some intractable problems: vaccines have low immunity to certain groups of people; repeated immunizations are required to produce better immunity; vaccine protection is prone to seriously decrease over time; There are no effective vaccines against infectious diseases. Therefore, many vaccines, especially new vaccines such as subunit vaccines, DNA vaccines and peptide vaccines, must produce stronger and longer-lasting immune responses to meet the needs. [0003] As an important class of substances that can improve the immune effect of vacci...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/08C07K14/465C12N15/12C12N15/70A61K39/39
Inventor 傅宏庆姚志兰张响英卢炜刘静
Owner 南京吉升和化工科技有限公司
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