Systems and methods for illumination phase control in fluorescence microscopy
A phase control and microscopy technology, applied in the field of fluorescence microscopy, can solve the problems of low optical distortion and slow switching time of deformable windows (about tens to hundreds of milliseconds, etc.)
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[0019] Various illumination phase control (“IPC”) are described along with a general description of three-dimensional structured illumination microscopy (“3D-SIM”). Compared with conventional wide-field fluorescence microscopes used in cell biology, 3D-SIM achieves a 1 / 2 increase in lateral and axial resolution. Unlike some competing super-resolution techniques, 3D-SIM does not require specialized fluorescent dyes or proteins. Biologists use 3D-SIM to achieve high resolution but retain the convenience and familiarity of fluorescent labeling. Illumination phase control provides the ability to shift and rotate the illumination pattern to capture multiple images of the subject. Higher resolution can be achieved by solving a system of equations to recover fine spatial details that are usually blurred by diffraction.
[0020] figure 1 A schematic representation of an example 3D-SIM instrument 100 is shown. There are many different types of SIM instruments and corresponding opti...
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