Oligonucleotide and its derivatives, and applications thereof

A technology of oligonucleotides and derivatives, applied in the field of oligonucleotides and derivatives thereof, can solve problems such as functional effects
CN103484460AInactive Publication Date: 2014-01-01RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Publication Date
2014-01-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides an oligonucleotide (5'-cagctccgcgctcggtgg-3') capable of reducing the high expression of a PML / RARalpha fusion protein related tissue factor (TF), and its derivatives, and applications of the oligonucleotide (5'-cagctccgcgctcggtgg-3') and its derivatives in the prevention and / or treatment of acute leukemia and its complications and / or other PML / RARalpha related tissue factor abnormal-high-expression or its acceptor activity abnormal-change related diseases, and / or the improvement of TF high-expression related pathology phenomena, such as coagulopathy.
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Description

technical field

[0001] The invention belongs to the technical field of cell bioengineering, and in particular relates to an oligonucleotide and its derivatives and their application. Background technique

[0002] Many patients with hematological malignancies often have obvious abnormal bleeding and coagulation signs in clinical practice. The reason is that in addition to platelet abnormalities, there are complex coagulation abnormalities (Tallman MS, Kwaan HC, Rev Clin Exp Hematol, 8( 1), E1, 2004; Nadir Y, Katz T, Sarig G, et al. Haematologica, 90(11), 1549-1556, 2005). Acute leukemia is often associated with coagulation dysfunction, and complications such as bleeding and thrombus are prone to occur. The abnormality of the coagulation system in acute leukemia is related to various factors such as the increased expression of tissue factor (Tissue Factor, TF) and the release of tumor procoagulant substances. The increased expression of TF is considered to be one of the main...

Claims

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