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Dispersible tablet for treating acute respiratory infection and preparation method thereof

A technology for respiratory tract and dispersible tablets, applied in the field of dispersible tablets for the treatment of acute respiratory tract infections and their preparation, can solve the problems of slow onset, inability to adapt, low bioavailability, etc., achieve rapid disintegration, improve dissolution rate, overcome bitter taste unbearable effect

Active Publication Date: 2015-10-28
成都中医大中医药健康产业技术研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the onset of the drug is slow, the bioavailability is low, and it cannot meet the requirements of patients with acute infection who want the drug to act quickly, so it needs to be made into a dosage form that is easy to take, absorb, and distribute quickly.

Method used

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  • Dispersible tablet for treating acute respiratory infection and preparation method thereof
  • Dispersible tablet for treating acute respiratory infection and preparation method thereof
  • Dispersible tablet for treating acute respiratory infection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Take 15g of baicalin, 3.75g of andrographolide, 5.625g of microcrystalline cellulose, and 5.625g of low-substituted hydroxypropyl cellulose, mix well, granulate with 60% ethanol in an appropriate amount, and dry at 50°C to 80°C. Sieve No. 4 to granulate, press into 100 pieces, and get ready.

Embodiment 2

[0045] Take 15g of baicalin, 3.75g of andrographolide, 5.625g of pregelatinized starch, and 5.625g of low-substituted hydroxypropyl cellulose, mix well, granulate with 60% ethanol in an appropriate amount, and dry at 50°C to 80°C. Sieve No. 4 to granulate, press into 100 pieces, and get ready.

Embodiment 3

[0047] Take 15g of baicalin, 3.75g of andrographolide, 5.625g of mannitol, and 5.625g of low-substituted hydroxypropyl cellulose, mix well, granulate with 60% ethanol in an appropriate amount, and dry at 50°C to 80°C. Sieve the whole grain, press into 100 pieces, that is.

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PUM

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Abstract

The invention provides a dispersible tablet for treating acute respiratory tract infection and a preparation method thereof. The invention also provides a method for modifying the taste of a prescription medicine, food, or a health-care product, and particularly provides a method for modifying the taste of raw herbal materials of a capsule for treating cold and cough. By adopting the preparation method provided by the invention, the dispersible tablet, which is rapid to digest, and good in appearance property, can be finally obtained by screening the medicine compatibility, such as the adjuvant types and the dosages, and researching the preparation method to ensure the improvement of the dissolution rate and bioavailability of a preparation for treating cold and cough.

Description

technical field [0001] The invention relates to a dispersible tablet for treating acute respiratory infection and a preparation method thereof. Background technique [0002] The main components of Ganke Shuangqing preparation are baicalin and andrographolide, which have the effects of clearing away heat, detoxification and anti-inflammation, and have a good curative effect on the treatment of acute upper respiratory tract infection, acute bronchitis and pneumonia. Acute respiratory infection is one of the most common clinical diseases, 90% of which are caused by virus infection, and bacterial infection is mostly secondary to virus infection, resulting in aggravation of the disease. In the early stage of virus infection, timely and effective inhibition of virus replication and transmission can prevent disease progression. return is of great significance. Modern pharmacological studies have found that andrographolide is a NF- k A partial inhibitor of the B signaling pathway ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/20A61P11/00A61P31/12A61P29/00A61K31/365
Inventor 韩丽张定堃秦春风张芳
Owner 成都中医大中医药健康产业技术研究院有限公司
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