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Film for hyperplastic scar repair and preparation method thereof

A technology for hypertrophic scars and sticking films, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, peptide/protein components, etc., can solve the problems of unobserved curative effect, immaturity, and adverse consequences, and achieve easy tissue absorption, Improves stability and promotes absorption

Active Publication Date: 2014-01-08
HENAN HUIBO MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the treatment of hypertrophic scars at home and abroad mostly adopts local drug sealing, skin transplantation, surgical excision and skin grafting, compression therapy, crystal scar grinding, etc., which are not very mature in clinical practice, and the curative effect remains to be seen.
Moreover, some take a long time, suffer a lot, are easy to repeat, and have adverse consequences, etc. Many of them are not satisfactory

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0037] The preparation method of the above-mentioned sticker includes the following steps:

[0038] 1) Prepare γ-interferon solution:

[0039] a. Take the said weight part of γ-interferon and dilute it with PBS containing 0.5-1.0% of human blood protein until the activity of γ-interferon is 0.3-0.6×10 8 IU / ml, used for sterilization and filtration; PBS is a phosphate buffer solution, used for molecular cloning and cell culture, pH=7.4, isotonic with human blood, the main components are potassium dihydrogen phosphate, disodium hydrogen phosphate, and chloride Sodium and potassium chloride;

[0040] 2) Prepare the liposome penetration enhancer in parts by weight:

[0041] b. Take the lecithin, sodium cholate and stearamide in parts by weight and dissolve it in 80-400 parts of ethanol, and perform reduced-pressure rotary evaporation at 28-33°C, with the rotation speed controlled at 90-110rpm, to The ethanol is completely evaporated;

[0042] 3) Encapsulate γ-interferon in liposomes to p...

Embodiment 1

[0051] A patch for repairing hyperplastic scars, which includes a backing layer, a viscous polymer layer, and an isolation layer that are sequentially bonded. The viscous polymer layer includes a viscous polymer, a liposome penetration enhancer and Scar active ingredient.

[0052] The weight ratio of the viscous polymer, liposome penetration enhancer and scar removal active component is: 200 parts of viscous polymer, 100 portions liposome penetration enhancer, 1 part of scar removal active component, 500 parts of glycerin;

[0053] The liposome penetration enhancer includes lecithin, sodium cholate and stearamide, and the weight ratio of the lecithin, sodium cholate and stearamide is: 60 parts of lecithin, 10 parts of sodium cholate, 1 part of stearamide.

[0054] The scar-removing active components include gamma-interferon, Va acid and Ve, and the weight ratio of gamma-interferon, Va acid and Ve is: 70 parts of gamma-interferon, 1 part of Va acid, and Ve 5 Copies.

[0055] The γ-i...

Embodiment 2

[0070] A patch for repairing hyperplastic scars, which includes a backing layer, a viscous polymer layer, and an isolation layer that are sequentially bonded. The viscous polymer layer includes a viscous polymer, a liposome penetration enhancer and Scar active ingredient.

[0071] The weight ratio of the viscous polymer, liposome penetration enhancer and scar removal active component is: 550 parts of viscous polymer, 300 portions liposome penetration enhancer, 10 parts of scar removal active component, 8,500 parts of glycerin;

[0072] The liposome penetration enhancer includes lecithin, sodium cholate and stearamide, and the weight ratio of the lecithin, sodium cholate and stearamide is: 80 parts of lecithin, 20 parts of sodium cholate, 7 parts of stearamide.

[0073] The scar-removing active components include gamma-interferon, Va acid and Ve, and the weight ratio of gamma-interferon, Va acid and Ve is: 650 parts of gamma-interferon, 12 parts of Va acid, and Ve 11 Copies.

[0074...

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PUM

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Abstract

The invention discloses a film for hyperplastic scar repair and a preparation method thereof. The film comprises a back lining layer, a viscous polymer layer and an isolation layer which are sequentially bonded, wherein the viscous polymer layer comprises a viscous polymer, a liposome permeation promoter and a scar removal active component and can keep good adhesiveness and cohesiveness in the case of moisture or sweat; meanwhile, with good hydrophilcity and lipophicity, the viscous polymer layer is more favorable for the medicine to penetrate through skin to promote medicine absorption, and a higher medicine-through-skin rate can be obtained. The film for hyperplastic scar repair, disclosed by the invention, takes effect quickly, the course of treatment is short, and the hyperplastic scar does not recur easily. The preparation method is simple, and the process cost is low.

Description

Technical field [0001] The invention relates to the technical field of scar repair, in particular to a patch for repairing hyperplastic scars and a preparation method thereof. Background technique [0002] Hyperplastic scars usually occur after the wounds of the dermis and deep burns have healed. The pathological difference between hyperplastic scars and normal scars is only the thickening of collagen fibers in the deep part of the scars, which are irregularly arranged, or wavy, or entangled into ropes. The hyperplastic scar has been constantly changing since it happened. At the beginning, the fibrous proliferation of the scar is rapid and numerous. After excessive fibrous proliferation, the blood vessels inside the scar are often compressed and gradually become ischemic. The hyperplastic scar appears as a prominent surface with irregular appearance and uneven height. Flushing and congestion, firm texture, burning pain and itching. Common incision scars after sutured incisions...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/21A61K9/70A61P17/02
Inventor 刘尧朱天钢李延浩
Owner HENAN HUIBO MEDICAL CO LTD
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