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Methods and compositions of protein antigens for the diagnosis and treatment of toxoplasma gondii infections and toxoplasmosis

A composition, technology of Toxoplasma gondii, applied in the direction of chemical instruments and methods, drug combinations, anti-infective drugs, etc., can solve unsatisfied problems

Inactive Publication Date: 2014-01-15
英珀特疗法有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Therefore, there remains a great, unmet need to provide improved compositions and methods of antigen and antibody detection and monitoring for T. gondii-related diagnostic and therapeutic applications

Method used

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  • Methods and compositions of protein antigens for the diagnosis and treatment of toxoplasma gondii infections and toxoplasmosis
  • Methods and compositions of protein antigens for the diagnosis and treatment of toxoplasma gondii infections and toxoplasmosis
  • Methods and compositions of protein antigens for the diagnosis and treatment of toxoplasma gondii infections and toxoplasmosis

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Experimental program
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Embodiment

[0057] Serum samples: Serum samples were divided into four groups. Group 1 consisted of seronegative individuals from Turkey with no known history of T. gondii infection. Group 2 consisted of sera from recently acute patients collected during an outbreak of toxoplasmosis. Sera were collected from these patients 1-2 weeks after the onset of symptoms. Group 3 consisted of chronically infected patients with persistent IgM antibodies and high IgG affinity index. Group 4 consisted of chronically infected patients who were negative for IgM antibodies and had a high IgG affinity index.

[0058] IgG Immunofluorescence Assay (IFA): IFA was performed by coating slides with HeLa cell culture and BALB / c derived T. gondii RH Ankara strain tachyzoites. Slides were then probed with 1 / 16, 1 / 64, 1 / 128, 1 / 256, 1 / 512, and 1 / 1024 diluted anti-Toxoplasma IgG positive patient serum samples at 37°C for 30 minutes and washed with PBS for 3 Second-rate. Slides were then probed with anti-human IgG...

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Abstract

Contemplated compositions, devices, and methods are drawn to various antigens from the pathogen T. gondii and their use in various diagnostic tests, vaccines, and therapeutic agents. In particularly preferred aspects, the antigens are immunodominant and have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and / or have a known association with a disease parameter.

Description

[0001] This application claims priority to US Provisional Patent Application Serial No. 61 / 426902, filed December 23, 2010, which is incorporated herein by reference. field of invention [0002] The field of the invention relates to selected Toxoplasma gondii ( Toxoplasma gondii ) compositions and methods of antigens, especially as it relates to their use in diagnostic and therapeutic compositions and methods. Background of the invention [0003] Toxoplasmosis is an epidemic caused by the intracellular protozoan Toxoplasma gondii. This organism has a complex life cycle involving both primary and secondary hosts. The primary host is the cat family ( Felidae ) family members, including domestic cats, who can transmit the organism to humans via T. gondii oocytes released in the feces of the primary host. In addition to humans, the organism infects a wide variety of secondary hosts, and these hosts can transmit T. gondii to humans via ingestion of tissue cysts containing tac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/012A61K39/00
CPCA61K39/002G01N33/56905A61P33/02C07K14/45
Inventor D.H.戴维斯梁小武P.费尔格纳
Owner 英珀特疗法有限公司
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