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Application of astragalus-salviae miltiorrhizae qi-benefiting dropping pills in resistance to anti-cancer medicine cardiotoxicity

A technology of Qishen Yiqi Dropping Pills and anticancer drugs, applied in the field of medicine, can solve the problems of unclear myocardial energy metabolism and the like

Inactive Publication Date: 2014-01-22
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, whether QSYQ can improve the myocardial structure and cardiac function damage caused by anticancer drugs in rats, and whether it can regulate myocardial energy metabolism is still unclear.

Method used

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  • Application of astragalus-salviae miltiorrhizae qi-benefiting dropping pills in resistance to anti-cancer medicine cardiotoxicity
  • Application of astragalus-salviae miltiorrhizae qi-benefiting dropping pills in resistance to anti-cancer medicine cardiotoxicity
  • Application of astragalus-salviae miltiorrhizae qi-benefiting dropping pills in resistance to anti-cancer medicine cardiotoxicity

Examples

Experimental program
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Effect test

Embodiment 1

[0084] Take astragalus 86.5g, salvia miltiorrhiza 21.3g, notoginseng 3.5g, jiangxiang 20.6g, and auxiliary material polyethylene glycol-600030g. Decoct the crushed salvia miltiorrhiza and Panax notoginseng in water twice, adding 7 times the amount of water each time for 2 hours each time, combining the decoction liquid, filtering, and concentrating the filtrate to 900ml, adding 95% ethanol to make the alcohol concentration reach 70%, let it stand for 12-24 hours, filter, recover ethanol, concentrate into an extract with a relative density of 1.32-1.38 (50-60°C); decoct the pulverized Astragalus membranaceus twice with water, adding 6 Double the amount of water, extract for 2 hours and 1 hour in turn, combine the filtrate, and when concentrated to about 1500ml, add 95% ethanol to make the alcohol concentration 60%, let it stand for 12-24 hours, filter, recover ethanol from the filtrate, and concentrate to about 400ml , add 95% ethanol to make the alcohol concentration 80%, let ...

Embodiment 2

[0086] Get Radix Astragali 40.6g, Salvia Miltiorrhiza 44.8g, Panax notoginseng 11.2g, Dalbergia 38.6g, adjuvant Polyethylene Glycol-600030g, make Chinese medicine preparation of the present invention by the preparation technology of embodiment 1.

Embodiment 3

[0088] Get astragalus 77.3g, salvia miltiorrhiza 22.8g, notoginseng 4.8g, jiangxiang 30.5g, adjuvant polyethylene glycol-600028g, and make the traditional Chinese medicine preparation of the present invention according to the preparation process of embodiment 1.

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Abstract

The invention discloses an application of astragalus-salviae miltiorrhizae qi-benefiting dropping pills in the resistance to anti-cancer medicine cardiotoxicity. The astragalus-salviae miltiorrhizae qi-benefiting dropping pills can be used for improving the myocardium loss and the cardiac function damage caused by anti-cancer medicines, the degradation of rat cardiac muscle ATP (Adenosine Triphosphate) caused by doxorubicin, the reduction of peroxisome proliferator-activated receptor alpha and the reduction of peroxisome proliferator-activated receptor gamma coactivator 1 alpha, alleviating the eccentric hypertrophy of myocardium and the myocardial damage, increasing the blood flow volume of heart surface and improving the cardiacfunction.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of Qishen Yiqi dripping pills in combating cardiotoxicity of anticancer drugs. Background technique [0002] Cancer and cardiovascular diseases (cardiovascular diseases, CVD) have become the leading causes of death in Chinese adults, and more than 70% of elderly cancer patients have CVD. Cancer patients with CVD increase the cardiovascular toxicity of anticancer chemotherapy drugs and increase the risk of chemotherapy. Studying the cardiovascular toxicity of chemotherapeutic drugs has important clinical implications for the treatment of cancer. [0003] Doxorubicin (DOX) belongs to anthracycline antibiotics and is currently one of the most effective antineoplastic drugs, but continuous use can lead to congestive heart failure, and its severe dose-dependent cardiotoxicity limits its clinical application. Myocardial damage caused by DOX is related to free radicals, imbalan...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/20A61P9/00A61P9/10
Inventor 韩晶岩唐东昕李萍萍赵海萍潘春水刘育英杨晓媛陈媛媛王传社
Owner TIANJIN TASLY PHARMA CO LTD
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