Ginkgol biloba extract delayed pulse capsule and quality control method thereof

A technology of Ginkgo biloba extract and delayed pulse is applied in the directions of medical raw materials, pharmaceutical formulations, and measuring devices derived from Ginkgo biloba. Controllable drug release behavior, reducing the link of tableting, and improving the effect of isolation
CN103536580BActive Publication Date: 2014-11-05ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2014-11-05

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Abstract

The invention relates to a ginkgol biloba extract delayed pulse capsule and a quality control method thereof and belongs to the technical field of pharmaceutic preparations. The ginkgol biloba extract delayed pulse capsule comprises an insoluble capsule body, ginkgol biloba extract quick release dropping pills, an isolated layer and a time delay layer which are arranged in the insoluble capsule body as well as a soluble capsule cap, wherein the isolated layer is made by adopting a water-soluble material, the time delay layer is made by adopting a macromolecule swelling material, and the isolated layer is arranged between the ginkgol biloba extract quick release dropping pills and the time delay layer. The ginkgol biloba extract delayed pulse capsule has the beneficial effects that firstly pulsed release is controlled by water absorption swelling time of a high polymer material of the time delay layer and is not influenced by variation of pH value of gastrointestinal tract or evacuation speed of the gastrointestinal tract of a patient, a time delay regulating range is wide, reproducibility is good, and individual difference is small; secondly, a traditional Chinese medicine raw material controlling method in HPLC (high performance liquid chromatography) fingerprint spectrum control is used for reference in the preparation quality control field, and the problem that quality of the existing traditional Chinese medicine multi-ingredient sustained-release preparation can not be controlled is solved.
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Description

technical field

[0001] The invention relates to a ginkgo extract delayed pulse capsule and a quality control method thereof, belonging to the technical field of pharmaceutical preparations. Background technique

[0002] The pulse drug delivery system is a timed drug delivery system designed according to the principles of chronopharmacology and chronotherapy. In view of the fact that cardiovascular and cerebrovascular diseases often occur in the early morning, a preparation with a time lag of 5-6 hours can be designed: the patient takes the medicine before going to bed (9-10 p.m.), and the drug is released before the onset of the disease (3-4 a.m.). It can effectively prevent and treat diseases and reduce side effects. Ginkgo biloba extract (EGS) has a wide range of pharmacological activities. Its treatment of cardiovascular and cerebrovascular diseases has definite curative effect and good safety. Its immediate release preparation (injection, etc.) is the first-line drug fo...

Claims

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