Tobramycin-dexamethasone eye drops

A technology of dexamethasone and tobramycin, which is applied in the direction of drug delivery, antibacterial drugs, organic active ingredients, etc., to achieve the effect of good redispersibility, good redispersion characteristics, and high content uniformity
CN103565816AInactive Publication Date: 2014-02-12TIANJIN JINYAO GRP
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN JINYAO GRP
Publication Date
2014-02-12
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The invention discloses tobramycin-dexamethasone eye drops. The tobramycin-dexamethasone eye drops contain tobramycin micro-powder and dexamethasone as active components, and also contain one or more accessory materials for eye drops. The tobramycin-dexamethasone eye drops are characterized in that the used dexamethasone micro-powder meets the grain size conditions that D50 is in a range of 3.0-4.0 microns, the maximum grain size is less than 30 microns, a ratio of micro-powder grains having sizes of 1-5 microns is in a range of 60-66%, a ratio of the micro-powder grains having sizes of 5-10 microns is in a range of 21-26%, and a ratio of the micro-powder grains having sizes less than or equal to 10 microns is in a range of 92-98%.
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Description

Technical field:

[0001] The invention relates to a compound eye drop of glucocorticoid and macrolide antibiotics. Background technique:

[0002] Tobramycin and dexamethasone eye drops are widely used in the treatment of ocular inflammation, Chinese literature "Development of Compound Tobramycin Eye Drops" (Yu Qingzhen, Shanghai Pharmaceuticals, Volume 20, No. 11, 1999, 36 -37) discloses a formula of tobramycin-dexamethasone eye drops, and discloses the particle size range and distribution of dexamethasone powder as the active ingredient. Nearly 99% of the drug particles are micropowders of 1-5 ฮผm. We found that the suspension prepared according to the particle size range of the drug can certainly meet the national standard, but due to the addition of suspending agents and other auxiliary materials, the viscosity of the liquid increases. After the suspension is completely precipitated by the drug particles, it takes a long time to shake to achieve good redispersion. The redi...

Claims

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