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Liquid drug composition of oxycodone

The technology of a liquid medicine and composition, applied in the nasal cavity drug delivery system or composition of oxycodone and its preparation, in the field of nasal spray preparation, can solve the problems of slow onset of tablet effect, inconvenient administration, difficulty in swallowing and the like

Active Publication Date: 2014-03-19
韩彬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the tablet has a slow onset of action and low bioavailability, and patients need to swallow it, while most advanced cancer patients have difficulty swallowing and administration is inconvenient; although the injection has a fast onset of action, it requires special medical staff to administer it, which is limited to hospitals use, and patients have to bear certain pain and high economic burden, increasing the cost of clinical medication

Method used

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  • Liquid drug composition of oxycodone
  • Liquid drug composition of oxycodone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Example 1: Oxycodone Hydrochloride Liquid Composition

[0078] Oxycodone Hydrochloride

[0079] Preparation method: add the above-mentioned amount of oxycodone hydrochloride and each auxiliary material into an appropriate amount of distilled water, stir well to dissolve all, and finally add distilled water to 100ml to obtain the liquid composition of the present invention. The obtained solution is divided into spray pumps or metered drop pumps to obtain sprays or drops that can be administered nasally.

Embodiment 2

[0080] Example 2: Oxycodone Hydrochloride Liquid Composition

[0081] Oxycodone Hydrochloride

[0082] Preparation method: Carry out with reference to the method of Example 1.

Embodiment 3

[0083] Example 3: Oxycodone Hydrochloride Liquid Composition

[0084] Oxycodone Hydrochloride

[0085] Preparation method: refer to the method of Example 1, the pH value of the solution is not adjusted, and the pH value of the final solution is 4.2.

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PUM

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Abstract

The invention relates to a liquid drug composition of oxycodone. The liquid drug composition disclosed by the invention comprises effective dose of oxycodone for treatment and / or prevention, or a pharmaceutically acceptable salt thereof, a preservative and water. The liquid drug composition of oxycodone disclosed by the invention has the advantages as mentioned in the specification. Particularly, according to the composition disclosed by the invention, oxycodone is prepared into a preparation for intranasal administration, such as a spray or a drop by adopting a unique formula. The liquid drug composition not only is convenient to use by a sufferer, but also can obtain anticipated high bioavailability.

Description

Field of Invention [0001] The invention relates to a liquid pharmaceutical composition of analgesic drug oxycodone, which can be used as a nasal cavity spray preparation. The invention also relates to a nasal administration system or composition of oxycodone and a preparation method thereof. Specifically, the nasal cavity delivery system of the present invention comprises oxycodone hydrochloride or its free base or other pharmaceutically acceptable salts of oxycodone, and optional pharmaceutically acceptable auxiliary materials. Background technique [0002] Oxycodone, chemical name: 4,5α-epoxy-14-hydroxy-3-methoxy-17-methyl-morphinan-6-one, English name: 4,5α-epoxy-14-hydroxy- 3-methoxy-17-methyl-morphinan-6-one. The structural formula is as follows: [0003] [0004] Molecular formula: C18H21NO4 Molecular weight: 315.37 [0005] Oxycodone hydrochloride is commonly used clinically, for example, the United States Pharmacopoeia usp35nf30, the British Pharmacopoeia BP20...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K9/08A61K31/485A61K47/40A61P25/04
Inventor 韩彬
Owner 韩彬
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