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Microcapsules and their preparation method

A technology of microcapsules and micropores, applied in the field of biomedical materials, can solve the problems of less active factors released, short survival time, and difficulty in attaching to scaffolds, etc., and achieve the effects of improving activity, prolonging life, and good biocompatibility

Active Publication Date: 2015-11-25
RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the harsh living environment of living cells, it is difficult to effectively attach to the scaffold, so the survival time is short, the release of active factors is less, and the sustained release effect is poor.

Method used

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  • Microcapsules and their preparation method
  • Microcapsules and their preparation method
  • Microcapsules and their preparation method

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Embodiment Construction

[0024] The microcapsules provided by the embodiments of the present invention and their preparation methods will be further described below in conjunction with the accompanying drawings.

[0025] see figure 1 and figure 2 , is the microcapsule 10 provided by the first embodiment of the present invention, the microcapsule 10 includes a microcapsule body 100 , a composite scaffold 200 and a cell 300 . The microcapsule body 100 is a fibrous membrane with a hollow closed space. The composite scaffold 200 and the cells 300 are disposed inside the microcapsule body 100 . The microcapsule body 100 includes a plurality of micropores 101 distributed on the surface of the microcapsule body 100 .

[0026] see image 3 , the microcapsule body 100 includes a microcapsule wall 102 and a hollow space surrounded by the microcapsule wall 102 . The composite scaffold 200 is disposed in the hollow space surrounded by the microcapsule wall 102 , specifically, the composite scaffold 200 is d...

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Abstract

The invention relates to a micro capsule which comprises a micro capsule body and a cell, wherein the micro capsule is provided with hollow enclosed space and comprises a plurality of micropores; and the micro capsule further comprises a composite scaffold arranged in the enclosed space of the micro capsule body, the composite stent comprises a scaffold and a coating layer covering the scaffold, the coating layer is made of a high polymer material with biocompatibility, and the cell is attached onto the composite scaffold. The invention further relates to a preparation method of the micro capsule.

Description

technical field [0001] The invention relates to a biomedical material, in particular to a microcapsule with biological sustained release effect. Background technique [0002] Active factors refer to a class of polypeptide substances that regulate cell growth and other cell functions by binding to specific, high-affinity cell membrane receptors. They are generally secreted by living cells and can act on damaged cells and nerves. etc. to repair and facilitate the survival and regeneration of cells. The discovery and application of this active factor brings hope to patients. [0003] In clinical practice, live cells are generally loaded into microcapsules with scaffolds, and then the microcapsules are placed in the lesion area to slowly release active factors. However, since living cells need a relatively harsh living environment, it is difficult to effectively attach to the scaffold, so the survival time is short, the active factor released is less, and the sustained release...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K35/00A61K47/42A61K47/36A61K47/34A61K47/32
Inventor 李小丽佘振定王明波姚瑶
Owner RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN