Anti-tumor drug composition and application thereof

An anti-tumor drug and composition technology, applied in the field of medicine, can solve the problems of high treatment cost, long drug effect time, large side effects and the like

Inactive Publication Date: 2014-03-26
王雪雁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the shortcomings of existing tumor therapeutic drugs in clinical application, especially the defects of large side effects and high trea

Method used

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  • Anti-tumor drug composition and application thereof
  • Anti-tumor drug composition and application thereof
  • Anti-tumor drug composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Example 1 Preparation of triptolide and alkylating agent antineoplastic drug microemulsion composition preparation

[0064] Prescription: triptolide 25g, carmustine 2.5g, glyceryl caprylate 30g, emulsifier OP50g, propylene glycol 20g.

[0065] Preparation method: Weigh 30 mg caprylic acid glyceride and 50 mg emulsifier OP, add to 20 mg propylene glycol, and mix evenly to obtain a suspension solution; accurately weigh 25 mg triptolide and 2.5 mg carmustine, respectively added to the suspension solution, and ultrasonically dissolved triptolide and carmustine to obtain the microemulsion concentrate of the composition of triptolide and carmustine; add water to the microemulsion concentrate obtained above The weight ratio of 1:10-20 is diluted to a clear solution to obtain a microemulsion.

Embodiment 2

[0066] Example 2 Preparation of triptolide and alkylating agent antineoplastic drug microemulsion composition preparation

[0067] The step of being processed into an anti-solid tumor pharmaceutical composition is the same as in Example 1, but the difference is that the anti-cancer active ingredient contained is the composition of triptolide and the following drugs: cyclophosphamide, nitrogen mustard, ifosf Carmustine, carmustine, lomustine, carmustine, carmustine, procarbazine, dacarbazine, semustine, niger Mustine, chlorambucil, hexamethylmelamine, thiotepa, Maryland, methoxymustine, methoxymustine, antitumor acid, antitumor mustard, nitrocarmust, pyrimidine mustard, methylurine Pyrimidine mustard, uracil mustard, mannitol mustard, phenylalanine mustard, dibromomannitol, formustine, o-alanine mustard, cytarabine, cyclohexyl nitrosourea.

Embodiment 3

[0068] Example 3 Preparation of triptolide and alkylating agent antineoplastic drug microemulsion composition preparation

[0069] Prescription: triptolide 0.01g, carmustine 10g, medium chain fatty acid glycerides 15g, polyoxyethylene castor oil EL-40 50g, 1,2-propanediol 12.5g, absolute ethanol 12.5g.

[0070] Preparation method: Weigh the prescription amount of medium-chain fatty acid glycerides, polyoxyethylene castor oil EL-40, 1,2-propylene glycol, and absolute ethanol, mix and stir evenly, then add triptolide and carmustine to dissolve, Ultrasonic treatment can also be used to speed up the dissolution to obtain a clear concentrated solution, which is the triptolide microemulsion concentrate; the microemulsion concentrate obtained above is diluted with water according to a weight ratio of 1:10-20 to a clear solution, and the microemulsion is obtained. milk.

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Abstract

The invention discloses an anti-solid tumor drug composition using a combination of triptolide and an alkylating agent as an active ingredient. The weight ratio of triptolide and the alkylating agent in the combination is 1 to (0.001-1000) and is further optimized to be 1 to (0.01-100). The anti-tumor drug composition disclosed by the invention comprises definite components, is wide in anti-tumor spectrum, has remarkable treatment effects on various tumors, is low in price and small in side effects, and has a good clinical application prospect.

Description

technical field [0001] The invention relates to an antitumor pharmaceutical composition and its application, in particular to a composition containing triptolide and an alkylating agent and its application for anti-solid tumors, and belongs to the technical field of medicines. Background technique [0002] Tumor is one of the common diseases that threaten human health, second only to cardiovascular disease. The research on tumor has made great progress, and a variety of radiotherapy, chemotherapy and other methods have been developed to treat tumors. However, various drugs and therapies There are limitations, it is difficult to achieve a radical effect, and prone to drug resistance and side effects. The mortality rate of cancer still ranks first in various diseases. According to available data, 3 million people died of cancer in my country in 2006, and the incidence of cancer is still on the rise, and there is a trend of getting younger. According to statistics, in less th...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P35/00A61P35/02A61K31/585
Inventor 刘学键
Owner 王雪雁
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