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Anti-thrombus sustained-release flavor composition

A slow-release composition, anti-thrombotic technology, applied in drug combination, blood diseases, food science and other directions, can solve the problems of leaf anti-thrombotic application that have not been reported

Inactive Publication Date: 2014-04-23
崔铠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the antithrombotic application of the leaves of Angelica sinensis from Tibet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0036] An antithrombotic sustained-release composition, consisting of

[0037] Tibetan Soil Angelica Leaf Extract 10mg

[0038] Psyllium Extract 1mg

[0039] Seasoning base 1mg

[0040] Hypromellose 50mg

[0041] Microcrystalline Cellulose 20mg

[0042] Magnesium Stearate 2mg

[0043] Mix the components of the sustained-release composition and the excipients except magnesium stearate evenly, make soft materials with 70% ethanol, granulate with 16 mesh, dry at 50°C, granulate with 16 mesh, and add magnesium stearate; The extended-release tablets are prepared on a tablet machine.

[0044] seasoning base

[0045] Step a, preparation of whey protein enzymatic hydrolyzate: take whey protein, add distilled water according to 50 times the weight of whey protein, add papain according to the enzyme addition amount of 30000U / g protein, adjust the pH to 7.5, and put it in a water bath at 50°C Reaction 5.5h. At the end of the enzymatic hydrolysis, put the enzymatic solution in...

specific Embodiment 2

[0049] An antithrombotic sustained-release composition, consisting of

[0050] Tibetan Soil Angelica Leaf Extract 20mg

[0051] Psyllium Extract 5mg

[0052] Seasoning Base 5mg

[0053] Hypromellose 100mg

[0054] Microcrystalline Cellulose 30mg

[0055] Magnesium Stearate 5mg

[0056] Mix the components of the sustained-release composition and the excipients except magnesium stearate evenly, make soft materials with 70% ethanol, granulate with 16 mesh, dry at 50°C, granulate with 16 mesh, and add magnesium stearate; The extended-release tablets are prepared on a tablet machine.

[0057] A seasoning base material is made according to the following preparation method:

[0058]Step a, preparation of whey protein enzymatic hydrolyzate: take whey protein, add distilled water according to 50 times the weight of whey protein, add papain according to the enzyme addition amount of 30000U / g protein, adjust the pH to 7.5, and put it in a water bath at 50°C Reaction 5.5h. At ...

specific Embodiment 3

[0062] Toxicology research

[0063] According to the "Technical Guidelines for Acute Toxicity Research of Traditional Chinese Medicine and Natural Medicines", the acute toxicity study was carried out. Kunming mice were used, half male and half male. Before the experiment, they were fasted for 12 hours, and the mice in the test group were given the solution according to the product of Example 2 with the maximum dosage, once in the morning and evening; the mice in the control group were given the same amount of normal saline. The body weight, diet, appearance, behavior, secretion, excretion, poisoning and death of mice in each group were observed for 14 consecutive days. The results showed that the maximum dose of 132g / Kg administered twice a day to mice was 132g / Kg, which was equivalent to 60 times the daily oral dose of an adult, and the mice had no symptoms of acute toxicity and no lesions in tissues and organs, indicating that this The invented product has good safety a...

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PUM

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Abstract

The invention relates to an anti-thrombus sustained-release composition which contains an aralia tibetana leaf extract, a pulicaria insignis extract, a sustained-release accessory and a seasoning base stock prepared from whey protein.

Description

technical field [0001] The invention relates to a health food collar, in particular to an antithrombotic slow-release composition. Background technique [0002] Tibetan angelica belongs to the genus Notopterygium of Umbelliferae N otopterygiumincisum Ting ex H. T. Chang , growing on hillsides and forest margins, at an altitude of 4-4.9 km, distributed in Linzhi, Qamdo, Dingqing and other places in Tibet, and also in Qinghai, Sichuan, Gansu, and Shaanxi. Tibetan soil angelica is different from Chinese medicine angelica, which belongs to angelica and belongs to the family of Umbelliferae Radix an gelica sinensis . There are two main types in Tibet, namely Aba Angelica A Angelica apaensis Shan et Yuan and peony leaf angelica Angeli ca aeoniaefolis Shan, er Yuan, sp. nov. . Tibetan angelica is a traditional Tibetan medicine, which has the functions of nourishing blood, nourishing blood, promoting blood circulation and removing stasis, regulating menstruation and relievin...

Claims

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Application Information

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IPC IPC(8): A23L1/29A23L1/226A61K36/28A61P7/02A23L33/00A23L27/20
CPCA23L33/00A23V2002/00
Inventor 崔铠李玲玲
Owner 崔铠