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Detection and removal of carious dentin tissue.

一种本质、龋牙的技术，应用在龋齿领域，能够解决没有提及龋齿检测等问题

Inactive Publication Date: 2014-04-23
RLS GLOBAL AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No mention is made of the detection of caries that have progressed into the dentin tissue (i.e. carious dentin tissue)

Method used

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  • Detection and removal of carious dentin tissue.
  • Detection and removal of carious dentin tissue.
  • Detection and removal of carious dentin tissue.

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0152] Two human permanent teeth that were extracted due to their severely carious tissue status and had no previous dental restoration were selected and analyzed by FTIR within 1 week after extraction. The outermost part of the carious lesion is removed. The remaining dental carious tissue was divided into 2 layers: 1 outer layer with discolored, soft and infected dental carious tissue, and 1 inner layer, observed as unstained, dug down by tactile manipulation to the estimated hardness of remaining healthy dentin. For each tooth, 1 sample was taken from healthy dentin and another sample was taken from the inner layer of carious tissue. After incubation in purified water, they were left to dry at ambient temperature. The dry weight of each dental sample was approximately 1 mg. Each sample was then mixed with potassium bromide (KBr) followed by FTIR inspection with a total pellet weight of 100 mg. Use a Mattson Cygnus100FTIR spectrophotometer at 4cm -1 resolution for IR an...

Embodiment 2

[0156] The purpose of this experiment was to observe the addition of the dyes SEEK, Acid Red 1, Fluorescent Yellow, a combination of Fluorescent Yellow and Acid Red 1, or 5-(2-2- Hydrazino-2-oxoethylthio)acetamido)-2-(3-hydroxy-6-oxo-6H-xanthene-9-yl)benzoic acid, Alexa Whether 594 and Alexa350 bind carious surfaces. The experiment was carried out over a period of 4 days.

[0157] Intact caries-infected teeth were incorporated into the original acrylic gel, which was used as a support after hardening, and then sawed (trademark of the saw was Zaw Micro Tone, Germany). Sections with a thickness of 150 μm were left overnight (day 1) in each dye to be tested. On day 2, the dye was washed off by rinsing the sections with MQ water, and pictures of the tooth sections were taken under a microscope (6.7×; visible light), in UV (no microscope), or under a fluorescence microscope (100×). Thereafter, saline solution (NaCl, 1M) was added to the sections and incubated overnight. On day...

Embodiment 3

[0164] Human permanent teeth that were extracted due to their severely carious tissue status and had not previously undergone dental restoration were selected and analyzed by FTIR within 1 week after extraction. The outermost part of the carious lesion is removed. The remaining dental carious tissue was divided into 2 layers: 1 outer layer with discolored, soft and infected dental carious tissue, and 1 inner layer observed as unstained and controlled by tactile manipulation Dig into the hard surface of remaining healthy dentin.

[0165] Healthy dentine tissue and carious dentine tissue from the innermost layer were collected. The healthy dentine tissue sample and the carious dentine tissue sample were then each divided into 3 samples.

[0166] Healthy dentin tissue samples (26 mg) were separated and processed as follows. Sample 1 (hereinafter referred to as S1) (11 mg) was repeatedly washed in purified water and placed under vacuum, defined as an untreated sample, ie a refe...

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Abstract

The present invention relates to a kit of parts for detection and removal of carious dentin tissue comprising: (i) one or more compounds being a hydrazine derivative, and (ii) means for chemical treatment of carious dentin tissue Further, the invention concerns a preparation containing an active, caries-dissolving two-component liquid in the form of a first active, caries-dissolving component and a second component which reduces the aggressiveness of the active component to mucous membranes, a viscosity increasing substance and one or more compounds being a hydrazine derivative. The hydrazine derivative labels carious dentin tissue selectively and substantially irreversibly in the presence of healthy dentin tissue, which is useful in the context of caries removal.

Description

technical field [0001] The present invention relates to dental caries. In particular, the present invention relates to the detection and selective removal of dental caries by chemical treatment when carious lesions have progressed into dentin tissue. Background technique [0002] In the treatment of carious lesions, large portions of carious tissue can be examined by judging the hardness of the affected surface using tactile instruments (so-called probing), and / or by visual observation of the well-known discoloration known as Maillard products. However, the caries-affected surface near the healthy dentin, which is called the pellucida, was not discolored. [0003] For early caries (in which caries affects only the enamel), a different therapy is used. In one therapy, caries-affected tissue is removed using a mechanical device such as a dental drill tool. Another therapy uses preventative methods, such as fluoridation. [0004] Incipient caries, ie caries affecting only t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/00
CPCA61K6/0061A61K6/002A61K6/0067A61K6/0047A61K6/007A61K6/70A61K6/66A61K6/60A61K6/69A61K6/25A61P1/02A61P43/00C08L1/286
Inventor U·阿尔姆胡杰德A·尼尔松
Owner RLS GLOBAL AB
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