The invention provides an artificial tooth adhesive composition, which comprises following components in parts by weight: 15 to 45 parts of water soluble polymer, 5 to 30 parts of alginate, 20 to 60 parts of mineral oil, and 1 to 10 parts of calcium sulfate. The adhesive composition is prepared from water soluble polymer, alginate, and mineral oil, thus prepared artificial tooth adhesive has a good bonding performance, at the same time, calcium sulfate cooperates with other components, and the artificial tooth adhesive is easy to clean. The adopted components are nontoxic, green, environmentally friendly, and thus the composition is safe to use.