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Application of trigoxyphin K in vasodilator drugs

A technique for dilating blood vessels and drugs, applied in the application field of TrigoxyphinK in the preparation of vasodilating drugs, and can solve problems such as no breakthrough progress

Active Publication Date: 2016-05-18
SHANGHAI STEPPHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of hypertension and its related vascular complications and / or complications mainly relies on western medicine, but there has been no breakthrough in the treatment of hypertension with traditional Chinese medicine

Method used

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  • Application of trigoxyphin K in vasodilator drugs
  • Application of trigoxyphin K in vasodilator drugs
  • Application of trigoxyphin K in vasodilator drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1: Preparation of Trigoxyphin K tablets, the compound involved in the present invention:

[0011] Take 5 grams of compound Trigoxyphin K, add 195 grams of dextrin, mix well, and conventionally press to make 1000 tablets.

Embodiment 2

[0012] Example 2: Preparation of TrigoxyphinK capsules of compound involved in the present invention:

[0013] Take 20 grams of the compound Trigoxyphin K, add 195 grams of starch, mix them, and encapsulate them to make 1000 tablets.

[0014] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0015] Experimental example 1 Preparation of isolated rat aortic ring

[0016] Experimental procedure: clean-grade male SD rats, experimental animal center of Nanjing Medical University, weighing 240-260 g. Quickly free the thoracic aorta of SD rats and place it at 4℃ containing 95% O 2 And 5% CO 2 In the K-H solution pre-saturated with mixed gas, remove the surrounding connective tissue and cut into a vascular ring of 3 to 4 mm. During the period, pay attention to protect the inner lining of the vascular ring from damage. According to the needs of the experiment, a cotton swab was used to rub the inner surface of the vascular ring to prepare a part of the vascular ring into a model with endothelium removed. Then the vascular ring is suspended in a bath with 10 mL of K-H solution, one end is fixed, and the other end is connected to the Medlab biological signal acquisition system through a tension transducer. Continuously pass 95% O2 and 5% CO 2 Under the state of mixed gas, adju...

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PUM

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Abstract

The invention increases the Trigoxyphin K application in the preparation of blood vessel expanding drugs, and relates the Trigoxyphin K application in the preparation of blood pressure lowering, antianginal and other anti-vascular-disease drugs. The Trigoxyphin K application in the preparation of the blood vessel expanding drugs is initially public, because a skeleton type belongs to a new type skeleton, the Trigoxyphin K blood vessel expanding activity is strong, the possibility of any enlightenment given by other compounds is not existed, and the Trigoxyphin K has prominent substantive features, and at the same time clearly has significant progresses in application in blood vessel expanding.

Description

Technical field [0001] The present invention relates to a new use of the compound TrigoxyphinK, in particular to the application of TrigoxyphinK in the preparation of vasodilator drugs. Background technique [0002] In our country, hypertension is a common cardiovascular disease with a high prevalence rate, and the mortality and disability rate of complications and / or comorbidities of the heart, brain, kidney, limbs and other blood vessels ranks first among various diseases. , It is extremely harmful to human health. According to the results of the 1991 national census, the prevalence of hypertension in my country has increased by 275% within 13 areas. At present, the treatment of hypertension and its related vascular complications and / or comorbidities mainly relies on western medicine, and there has not been a breakthrough in the use of traditional Chinese medicine for the treatment of hypertension. [0003] The compound TrigoxyphinK involved in the present invention is a new co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61P9/08A61P9/10A61P9/12
Inventor 田丽华
Owner SHANGHAI STEPPHARM CO LTD