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A technology of 18AA-V and compound amino acid, which is applied in the field of preparation of compound amino acid injection (18AA-V) composition, can solve unreasonable problems, achieve good effect, eliminate side effects, and ease degradation
Active Publication Date: 2014-05-21
湖北一半天制药有限公司
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In addition, compound amino acid injection (18AA-V) contains several amino acid hydrochlorides such as arginine hydrochloride, histidine hydrochloride, histidine hydrochloride and cysteine hydrochloride. The pH value of the solution is already close to 5.5. It is obviously unreasonable to adjust the pH value with citric acid
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Embodiment 1
[0052] A compound amino acid injection 18AA-V composition, characterized in that every 1000mL injection contains the following components:
[0053]
[0054]
[0055] Add water for injection to 1000mL;
[0056] The pH value of the injection is 6.2;
[0057] The preparation method of above-mentioned compound amino acid injection 18AA-V, its steps are:
[0058] A. Add 700mL of fresh water for injection into the liquid preparation tank, inject pure nitrogen gas, start stirring, and set aside for later use. Nitrogengas protection is always used in the following preparation processes.
[0060] C. After stirring to dissolve, lower the temperature to 80 or 81 or 83 or 84 or 85°C, add glutamic acid and phenylalanine, and stir to dissolve.
[0061] D. After stirring to dissolve, lower the temperature to 60 or 64 or 68 or 75°C, a...
Embodiment 2-7
[0069] A compound amino acid injection 18AA-V composition, characterized in that each 1000mL injection contains the following components, for convenience, the pH value of each formulation composition is written in the last line:
[0070]
[0071]
[0072] Its preparation method is all identical with embodiment 1.
[0073] The technical scheme of the present invention will be further described by following related tests:
[0074] One, the stability comparative test of the similar product containing sodiumbisulfite commercially available of embodiment 1 gained product:
[0075] The product obtained in Example 1 is the test group, and the commercially available compound amino acid injection (18AA-V) is used as the control group (add 0.05% (w / v) sodiumbisulfite, and adjust the pH value of the solution to about 6.2 with sodiumhydroxide) .
[0076] The prescription of the commercially available compound amino acid injection (18AA-V) containing sodium bisulfite is as follo...
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technical field [0001] The present invention relates to the field of medical technology, more specifically to a compound amino acid injection (18AA-V) composition, and also to a preparation method of a compound amino acid injection (18AA-V) composition. The product of the invention is suitable for nutrition Nutritional support for patients with malnutrition, hypoalbuminemia and before and after surgery. Background technique [0002] Compound Amino Acid Injection (18AA-Ⅴ) is a parenteral nutritiondrug, which is a sterilized aqueous solution prepared from 18 kinds of amino acids and xylitol. It is a balanced amino acid injection and plays an extremely important role in clinical application. The composition conforms to the Vuj-N formula ratio, the essential amino acids conform to the human milk-whole protein mode, and the non-essential amino acids conform to the human serum protein mode. The ratio of essential amino acids to non-essential amino acids is 1.04:1, each amino ac...
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