4 results about "Histidine Hydrochloride" patented technology

The invention discloses a pharmaceutical composition containing an anti-CD73 antibody and application of the pharmaceutical composition. The pharmaceutical composition is a liquid preparation containing an anti-CD73 antibody, and the liquid preparation comprises the following components: (A) 10-150 mg / mL of the anti-CD73 antibody or an antigen binding fragment of the anti-CD73 antibody; (B) 10 to 50 mM of a histidine-histidine hydrochloride buffer solution; (C) 150 to 280 mM of sucrose; (D) 5 to 20 mM of methionine; (E) 0.005% to 0.5% of a surface active agent; and (F) 0.005 to 0.1 mg / mL of a complexing agent. The pharmaceutical composition provided by the invention can provide better physical and chemical stability of the anti-CD73 antibody, and has a wide industrial application prospect.

Provided is a transfection reagent, comprising a solvent, organic substances, amino acids, vitamins and inorganic salts, wherein the organic substances comprise D-glucose, sodium pyruvate, i-inositol, phenol red and choline chloride; the amino acids comprise glycine, L-glutamine, L-valine, L-isoleucine, L-leucine, L-threonine, L-lysine hydrochloride, L-phenylalanine, L-serine, L-tyrosine disodium salt, L-arginine hydrochloride, L-methionine, L-cystine dihydrochloride, L-histidine hydrochloride and L-tryptophan; the vitamins comprise nicotinamide, pyridoxine hydrochloride, thiamine hydrochloride, folic acid, D-calcium pantothenate and riboflavin; and the inorganic salts comprise sodium chloride, sodium bicarbonate, potassium chloride, calcium chloride, sodium dihydrogen phosphate, magnesium sulfate, hydrochloric acid and ferric nitrate. The transfection reagent is suitable for a wide range of applications, achieves the rapid onset of transfection, and has a good transfection effect.

The present invention relates to a stable secukinumab injection, characterized in that it comprises 50-250 mg / ml of secukinumab, 5-50 mmol / l of histidine and histidine hydrochloride, 5-40 mmol / l of methionine, 150-370 mmol / l of low molecular weight sugar alcohol and polysorbate 80 at 0.01%-0.02% (v / v), in water for injection, pH 5.0-7.0, wherein the low molecular weight sugar alcohol is xylitol.

The invention discloses a high-concentration antibody preparation and application thereof, and belongs to the technical field of antibody pharmaceutical preparations, the preparation takes an antibody as an active ingredient, adopts glutamic acid and histidine hydrochloric acid buffer solution, is matched with non-ionic saccharide and sugar alcohol auxiliary materials, and uses a non-ionic buffer system to maintain the pH value of the system stable; and the stability risk caused by the ionic auxiliary material is reduced. The preparation can realize high-concentration preparation of more than 100mg / mL, obviously inhibits antibody aggregation, fragmentation and oxidative degradation, improves purity, stability and injection convenience, and is suitable for subcutaneous injection. The problems that a traditional high-concentration antibody preparation is prone to aggregation, high in viscosity, poor in stability and the like are solved, the prescription is scientific and controllable, and the method is suitable for clinical transformation and large-scale production.