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Cardioplegic solution

A technique of cardioplegia solution and buffer solution, applied in the field of medical drugs, can solve the problems affecting the quality of life of patients, cardiac insufficiency, and high probability of arrhythmia, and achieve the effect of reducing the incidence of cardiac insufficiency and protecting the heart.

Inactive Publication Date: 2014-07-23
王寿世
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  • Abstract
  • Description
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Problems solved by technology

[0004] Cardioplegia currently used clinically uses high-concentration potassium ions. High-concentration potassium ions can quickly arrest the heart, but high-concentration potassium ions can damage heart cells and coronary artery endothelial cells, resulting in cardiac insufficiency or even failure to recover after cardiac surgery. There are not many preventive methods at present, and the probability of arrhythmia after heart re-beating is relatively high, which greatly affects the quality of life of patients after surgery

Method used

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Embodiment 1

[0023] The cardioplegia solution of the present embodiment comprises the following components in the following mmol amounts in the Krebs-Henseleit solution of every 1000ml:

[0024]

[0025] The cardiac arrest solution of the present embodiment is prepared according to the following method:

[0026] At room temperature, NaCl, KCl, MgCl 2 6H 2 O, histidine, histidine hydrochloride, tryptophan, α-ketoglutarate, raffinose, adenosine and sodium channel blockers are taken according to the above mmol quantity, and added to 1000ml of Krebs-Henseleit In the solution, 3 mmol of glutathione was further added to the above solution before use in surgery.

[0027] The Krebs-Henseleit buffer preparation method is: add Na in 1000mL distilled water 2 CO 3 1.59g and NaHCO 3 After 2.93g, stir well.

[0028] Lidocaine is a sodium channel blocker, which blocks the sodium channel of heart cells, prevents action potentials from occurring, and stops the heart. Adenosine is an antiarrhythmic...

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Abstract

The invention discloses acardioplegic solution. Per 1000 mL of a bicarbonate buffer solution comprises 15 mmol of NaCl, 10 mmol of KCl, 4 mmol of MgCl2.6H2O, 180 mmol of histidine, 18 mmol of histidine hydrochloride, 2 mmol of tryptophan, 1 mmol of alpha-ketoglutaric acid, 30 mmol of raffinose, 3 mmol of glutathione, 0.2 mmol of adenosine and 0.6-0.8 mmol of a sodium channel blocker. The cardioplegic solution effectively protects heart and helps to reduce occurrence rate of postoperation cardiac insufficiency.

Description

technical field [0001] The invention relates to the technical field of medical medicines, in particular to a cardioplegia solution. Background technique [0002] Cardiac surgery is a relatively common operation in surgery. During the operation, it is necessary to support the patient's circulation and protect the patient's heart on the other hand. The protective effect of hypothermia has been applied and recognized not only locally in the heart but also in the whole body. Subsequent developments mainly used the gradual improvement of extracorporeal circulation components, which allowed more and more complex and longer-term operations, but the protective effect on the heart has not yet reached the ideal state, and cardiac arrest-reperfusion injury still exists after surgery. . [0003] In cardioplegia, the solution is perfused antegradely through the coronary arteries, or retrogradely through the coronary veins, to induce the heart to stop beating. [0004] Cardioplegia cur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/06A61P9/00A61K31/167A61K31/7076A61K31/245A61K31/445A61K31/529
Inventor 王寿世宋婷婷
Owner 王寿世
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