In-vitro energy supply substance suitable for skin collagen synthesis, raw material and preparation method

A collagen synthesis and substance technology, applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effect of lifting the skin, improving fine lines and reducing skin sagging

Pending Publication Date: 2021-10-19
杭州拾珍医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, it is generally amino acid raw materials that provide nutrition to the skin. However, it is difficult to convert the amino acid raw materials injected in

Method used

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  • In-vitro energy supply substance suitable for skin collagen synthesis, raw material and preparation method
  • In-vitro energy supply substance suitable for skin collagen synthesis, raw material and preparation method
  • In-vitro energy supply substance suitable for skin collagen synthesis, raw material and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] An in vitro energy-supplying substance and raw material suitable for skin collagen synthesis, each 1000ml contains: 2.45 grams of L-proline; 2.45 grams of L-serine; 4.85 grams of L-alanine; L-isoleucine 8.50 g; L-Leucine 11.81 g; L-Aspartic Acid 5.80 g; L-Tyrosine 0.65 g; L-Glutamic Acid 1.85 g; L-Phenylalanine 12.85 g; L-Arginine Hydrochloride L-lysine hydrochloride 12.00 grams; L-lysine hydrochloride 10.32 grams; L-valine 8.44 grams; L-threonine 6.05 grams; L-histidine hydrochloride 6.00 grams; L-tryptophan 1.96 grams; 5.45 grams of amino acid; 0.20 grams of L-cystine; 18.24 grams of glycine; 40 grams of hyaluronic acid; 3 grams of tranexamic acid; 50 grams of glucose; 0.5 grams of sodium bisulfite; 2 grams of dimethylaminoethanol; appropriate amount of water for injection .

[0018] A method for preparing an in vitro energy-supplying substance and raw material suitable for skin collagen synthesis, comprising the following steps:

[0019] 1) Take water for injection...

Embodiment 2

[0027] An in vitro energy-supplying substance and raw material suitable for skin collagen synthesis, each 1000ml contains: 2.45 grams of L-proline; 2.45 grams of L-serine; 4.85 grams of L-alanine; L-isoleucine 8.50 g; L-Leucine 11.81 g; L-Aspartic Acid 5.80 g; L-Tyrosine 0.65 g; L-Glutamic Acid 1.85 g; L-Phenylalanine 12.85 g; L-Arginine Hydrochloride L-lysine hydrochloride 12.00 grams; L-lysine hydrochloride 10.32 grams; L-valine 8.44 grams; L-threonine 6.05 grams; L-histidine hydrochloride 6.00 grams; L-tryptophan 1.96 grams; 5.45 grams of amino acid; 0.20 grams of L-cystine; 18.24 grams of glycine; 40 grams of hyaluronic acid; 3 grams of tranexamic acid; 50 grams of glucose; 0.70 grams of rosmarinic acid; 2 grams of dimethylaminoethanol; .

[0028] A method for preparing an in vitro energy-supplying substance and raw material suitable for skin collagen synthesis, comprising the following steps:

[0029] 1) Take the water for injection and heat it to 85°C, blow in nitrogen...

Embodiment 3

[0037] In this embodiment, rats are taken as an example to conduct experiments.

[0038] The purchased 56 healthy SD male rats were divided into 7 groups, among which 6 groups of rats were established as aging models, and D-galactose 150mg / kg / d was injected for six consecutive weeks to make a subacute aging model induced by D-galactose. By not doing injection treatment, only injecting AA, only injecting dimethylaminoethanol, only injecting normal saline, injecting Example 1 and Example 2 and healthy SD rats, injecting once a week, and killing the rats after 6 consecutive weeks, Rat skin was taken, and the content of hydroxyproline was detected to determine the content of collagen.

[0039] grouping and processing

[0040] The first group: aging rats, no injection treatment.

[0041] The second group: aged rats, only injected with normal saline.

[0042] The third group: aged rats, only injected with AA.

[0043] The fourth group: aged rats, only injected with dimethylamino...

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PUM

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Abstract

The invention discloses an in-vitro energy supply substance suitable for skin collagen synthesis, a raw material and a preparation method. The in-vitro energy supply substance comprises proline or L-proline; a serine or an L-serine; an alanine or an L-alanine; an isoleucine or an L-isoleucine; a leucine or an L-leucine; aspartic acid or L-aspartic acid; tyrosine or L-tyrosine; glutamic acid or L-glutamic acid; phenylalanine, or L-phenylalanine; arginine hydrochloride or L-arginine hydrochloride; lysine hydrochloride or L-lysine hydrochloride; a valine or an L-valine; threonine, or L-threonine; histidine hydrochloride or L-histidine hydrochloride; tryptophan, or L-tryptophan; a methionine or an L-methionine; cystine or L-cystine; glycine; hyaluronic acid; tranexamic acid; glucose; sodium hydrogen sulfite or rosmarinic acid; dimethylaminoethanol; and the balance of water for injection. The traditional Chinese medicine composition can supplement water, preserve moisture, tighten and lift the skin, relieve skin sagging and improve fine lines, wrinkles, aging and the overall texture and color of the skin.

Description

technical field [0001] The invention relates to a skin nutrition compound, in particular to an in vitro energy supply material and raw material suitable for skin collagen synthesis and a preparation method. Background technique [0002] At present, it is generally amino acid raw materials that provide nutrition to the skin. However, it is difficult to convert the amino acid raw materials injected into the human body into the required collagen in the existing technology, and there is a lack of energy supply for the transformation of amino acids into collagen. substance. Contents of the invention [0003] In order to solve the defects and deficiencies in the above-mentioned prior art, the present invention provides an energy-supplying substance for synthesizing human skin collagen, amino acids, and dimethylaminoethanol that synergizes with amino acids, and adds hyaluronic acid Moisturizing, adding tranexamic acid to brighten skin tone, firming and lifting skin, reducing ski...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61K8/23A61K8/37A61K8/44A61K8/49A61K8/60A61Q19/00A61Q19/08
CPCA61K8/4913A61K8/44A61K8/4946A61K8/492A61K8/735A61K8/60A61K8/23A61K8/37A61Q19/08A61Q19/00A61K2800/91A61K2800/522A61K2800/5922
Inventor 罗金凤王稹
Owner 杭州拾珍医疗器械有限公司
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