38 results about "Arginine hcl" patented technology

Stable liquid pharmaceutical compositions comprising an antagonist anti-CD40 antibody as a therapeutically or prophylactically active component and methods useful in their preparation are provided. These compositions comprise the antagonist anti-CD40 antibody, a buffering agent to maintain the pH of the composition between about pH 5.0 and about pH 7.0, and an amount of arginine-HCl sufficient to render the liquid composition near isotonic. The stable liquid antagonist anti-CD40 antibody-containing pharmaceutical compositions of the invention find use in methods for treating proliferative diseases and diseases having an autoimmune and / or inflammatory component.

The invention discloses an antioxidant probiotic facial mask and a preparation method thereof, and relates to the technical field of medical treatment and health care; the facial mask comprises an active component, a beneficial component and water, wherein the active component comprises a 24-7 strain fermentation product; the beneficial component comprises an algae extract, glycerin, lubrajel, camellia seed oil, saccharide isomers, CALMYANG, citron peel oil, tocopheryl acetate, dihydroxypropyl arginine HCl, polyglycerol-10 laurate, a hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, a chondrus crispus extract and allantoin. The preparation method is simple in process, the production cost is reduced, and it is guaranteed that industrialization can obtain good benefits; and the preparation method provided by the invention is high in embedding efficiency of the active component and good in coating effect, so that the absorptivity of the active component is improved.

The invention discloses a medicine composition containing an antibody coupling medicine, a freeze-drying agent, and a preparation method and a purpose of the medicine composition and the freeze-dryingagent. The medicine composition comprises the following ingredients in parts by weight: 3-20mg / mL of F0002-ADC, 5-50mM of pH value buffering agents, 10-100mg / mL of protein protection agents, 0.05-2.0mg / mL of surfactant and 0-50mg / mL of arginine hydrochloride of which the pH value is 5-7. The medicine composition (preparation) containing the F0002-ADC antibody coupling medicine greatly eliminatesthe problems that the solubleness of the medicine is low (a medicine solution is under a clear state) and druggability is poor, and the water content of a freeze-drying drying preparation is lowered.A long-term stability experiment verifies that the formula can meet the clinical requirement of the F0002-ADC. The medicine composition or the freeze-drying agent prepared from the medicine composition has a good application prospect in preparation of medicines capable of treating CD30 positive tumors.

The invention discloses compound amino acid injecta, which contains arginine hydrochloride, histidine monohydrochloride, leucine, isoleucine, lysine hydrochloride and the like; meanwhile, the invention further discloses a preparation method of the compound amino acid injecta (18AA); in the event of ensuring the product quality, the compound amino acid injecta has the characteristics of saving energy and enhancing efficacy; by means of repetitive verification on precision, detection limit, quantitation limit, linear range and the like, a simple, convenient, rapid and reliable method with cleaning verification is ensured; furthermore, the residual quantity of antioxygen, namely sodium hydrogensulfite, in the compound amino acid injecta and sulphate ion generated by degrading sodium hydrogensulfite are detected according to an ion chromatography principle, thus, the amount of the antioxygen charged in the raw material proportioning can be accurately measured, and the stability of the raw material proportioning process is judged according to the measurement result; and a detection method of the compound amino acid injecta provided by the invention is an online derivative amino acid content measuring method, the speed is rapid, and the method is applied to large-scale detection.

The present invention relates to a stabilized pharmaceutical preparation of R27T, the preparation comprising a human interferon beta variant (R27T), an acetate buffer, arginine, trehalose, Poloxamer 188, and methionine. The stabilized R27T pharmaceutical preparation according to the present invention is obtained by the development of a preparation having a novel composition through the substitution of mannitol with trehalose in the composition of a preparation containing mannitol, which was previously studied by the present inventors. It was confirmed that the preparation can remedy a disadvantage of the protein aggregate increase due to the mixing and addition of mannitol and arginine HCl and can improve thermodynamic / structural stability and the resulting stability during the long-term storage, and thus it is expected that the preparation can be advantageously used in the prevention, alleviation, and treatment of multiple sclerosis, cancer, autoimmune diseases, viral infectious diseases, HIV infectious diseases, hepatitis C, rheumatoid arthritis, and the like.

The invention belongs to the field of daily chemicals. A multi-directional scalp care composition containing arginine derivatives, comprising the following components calculated by weight percentage: 30-45% polyhydroxy moisturizing agent with carbon chain length of C3-C6, pyrrolidone carboxylate 30-45% 45%, dihydroxypropyl arginine HCl 0.5-20%, bacteriostatic agent 0.1-25%, anti-inflammatory agent 0.1-10% and the balance of water. The composition of the invention is mild and non-irritating, moisturizing and moisturizing, antibacterial and anti-inflammatory, soothing and oil control, good anti-dandruff effect, effectively alleviating scalp problems such as itchy scalp, scalp inflammation, scalp tightness, etc., can make hair soft and antistatic, and has Good elasticity and gloss.

The invention discloses essence with a long-lasting moisturizing effect and a preparation method thereof. The essence is prepared from the following raw material components in percentage by mass: 5 to15 percent of long-lasting moisturizing complexing agent, 80 to 90 percent of solvent, 0.1 to 1 percent of thickener, 0.1 to 1 percent of pH conditioning agent, 0.5 to 1 percent of skin conditioner,0.2 to 1 percent of preservative and 0.05 to 0.5 percent of aromatic. The long-lasting moisturizing complexing agent is prepared from 10 to 25 percent of honey extract, 20 to 40 percent of rock mapleextract, 15 to 30 percent of saccharomycete / rice fermentation product filtrate, 0.5 to 5 percent of arginine HCl, 0.5 to 5 percent of lysine HCl, 0.5 to 5 percent of ornithine HCl, 0.5 to 5 percent ofceramide 3, 0.5 to 5 percent of ceramide 6II, 0.5 to 5 percent of ceramide 1, 10 to 20 percent of sodium lauroyl lactylate, 0.5 to 5 percent of phytosphingosine and 0.5 to 5 percent of cholesterol. The long-lasting moisturizing essence has a moisturizing effect lasting for 4 to 8 hours through optimization of the compounding and adding proportion of the long-lasting moisturizing complexing agent.

The invention relaets to a compound amino acid freeze-dried powder injection, which comprises L-arginine hydrochloride, L-histidine hydrochloride, L-leucine, L-isoleucine, L-lysine hydrochloride, L-phenylalanine, L-threonine, L-valine, L-methionine, L-tryptophan, glycine, L-alanine, L-proline, L-tyrosine, L-serine, L-cysteine hydrochloride, L- aspartic acid, L-glutamic acid and sodium bisulphate. Its preparing process is also disclosed in the invention.

The present invention relates to compound amino acid capsules and a preparation method thereof, and belongs to the technical field of health food preparation. The compound amino acid capsules comprise the following four groups of components that (1) the first group of the components comprises 1-10 parts of a ginseng extract, and 1-10 parts of a panax notoginseng extract; (2) the second group of the components comprises 20-30 parts of tryptophan; (3) the third group of the components comprises 10-30 parts of leucine, 10-20 parts of phenylalanine, 20-50 parts of threonine, and 20-40 parts of valine; and (4) the fourth group of the components comprises 10-30 parts of arginine hydrochloride, 10-20 parts of histidine hydrochloride, 20-50 parts of isoleucine, 10-30 parts of lysine hydrochloride, and 40-80 parts of methionine. The preparation method comprises: respectively adding the four groups of the components into a sugarcoating jar, intermittently spraying an adhesive by using a high pressure spraying gun, continuously rolling the components in the pot and intermittently adding the components to prepare pellets, carrying out pellet selection, drying and coating on the prepared pellets, uniformly mixing, and loading into capsules so as to obtain the finished product. The compound amino acid capsules have characteristics of high active ingredient, strong functionality, stable performance, and convenient oral taking.

The invention discloses a preparation method of L-arginine hydrochloride, which belongs to the technical field of separation and extraction. In the method of the present invention, the arginine fermentation liquid is firstly adsorbed with a strong-acid cation exchange resin, eluted with a sodium hydroxide solution to obtain an arginine solution, then adsorbed with a weakly acidic cation-exchange resin, and eluted with hydrochloric acid. Obtain arginine hydrochloride solution, and finally decolorize and concentrate to obtain arginine hydrochloride; the method of the present invention avoids elution with ammonia water, and no longer needs to use a large amount of steam to catch ammonia, thereby saving costs ; Simultaneously, this method has introduced novel resin technology, can remove the acidic and neutral amino acid impurity in arginine hydrochloride, the arginine hydrochloride purity that makes preparation is higher, and improved arginine to a great extent Yield and preparation efficiency of hydrochloride finished product.