Compound amino acid enteric-coated tablet for dog and preparation method thereof

A compound amino acid, enteric-coated tablet technology, applied in pharmaceutical preparations, animal husbandry and veterinary fields, can solve the problems of large side effects of drugs, inability to improve the nutritional status of dogs, and slow growth of dogs.

Inactive Publication Date: 2020-10-27
HEBEI KEXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Nowadays, more and more families choose to domesticate dogs as pets, but some dogs are weak and sick. Under normal circumstances, they often show symptoms such as decreased appetite, reduced food intake, and physical weakness. If the above symptoms are not improved in time, it will cause the dog to grow slowly or even die.
[0003] At present, the replenishment liquids used to enhance the dog's physical performance are mainly glucose and sodium ch...

Method used

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  • Compound amino acid enteric-coated tablet for dog and preparation method thereof
  • Compound amino acid enteric-coated tablet for dog and preparation method thereof
  • Compound amino acid enteric-coated tablet for dog and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～6

[0021] Examples 1-6 Preparation method of compound amino acid enteric-coated tablets for dogs

[0022] Examples 1-6 are respectively a preparation method of compound amino acid enteric-coated tablets for dogs. The composition of raw materials for making compound amino acid enteric-coated tablets for dogs is shown in Table 1. The immediate-release coating powder and enteric-coated powder in Examples 1-6 are All the dissolving coating powders were purchased from the market, and the process parameters for preparing compound amino acid enteric-coated tablets for dogs are shown in Table 2.

[0023] The preparation method is carried out according to the following steps:

[0024] S1. Preparation of tablet core: weigh leucine, isoleucine, valine, glycine, proline, alanine, lysine hydrochloride, arginine hydrochloride, serine, threonine, histamine hydrochloride Acid, methionine, phenylalanine, tryptophan, starch and part of carboxymethyl starch sodium are added to the wet granulator, ...

Embodiment 7

[0032] Example 7 Effectiveness Test of Compound Amino Acid Enteric-coated Tablets for Dogs

[0033] Select 90 Beagle dogs clinically diagnosed as protein deficiency, and divide them into 6 groups, namely control group 1, control group 2, control group 3, test group 1, test group 2 and test group 3, with 15 dogs in each group. The sick dog showed emaciation, weight loss, and loss of appetite. Beagles were treated according to the usage and dosage in Table 1, and observed for 7 days. The test results are shown in Table 3.

[0034] Table 3 Results of effectiveness test of compound amino acid enteric-coated tablets for dogs

[0035]

[0036] It can be seen from Table 3 that after 7 days of treatment and observation, dogs in the control group 1 to 3 had vomiting reactions, and no vomiting reactions were seen in the test groups 1 to 3, and the dogs in the test groups 1 to 3 had increased food intake and body weight. also increased. The test results show that the compound amino ...

Embodiment 8

[0037] Example 8 Detection test of compound amino acid enteric-coated tablets for dogs

[0038] According to the "People's Republic of China Veterinary Pharmacopoeia" 2015 edition two appendix 0921 disintegration time limit inspection method, respectively take 6 enteric-coated tablets prepared in Examples 1-6, place them in artificial gastric juice for 2 hours, observe the enteric-coated tablets Whether the appearance is damaged or fragmented; after washing with a small amount of water, put it into the artificial intestinal juice immediately, the time for the complete disintegration of the enteric-coated tablets, each tablet should be completely disintegrated within 1 hour. The test results are shown in Table 4.

[0039] Table 4 Detection test results of compound amino acid enteric-coated tablets for dogs

[0040]

[0041]It can be seen from Table 4 that the enteric-coated tablets prepared in Examples 1-6 have no appearance of broken fragments in gastric juice, and all dis...

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Abstract

The invention belongs to the field of pharmaceutical preparations, and particularly discloses a compound amino acid enteric-coated tablet for dogs and a preparation method thereof. The compound aminoacid enteric-coated tablet is prepared from raw materials of effective components including leucine, isoleucine, valine, glycine, proline, alanine, lysine hydrochloride, arginine hydrochloride, serine, threonine, histidine hydrochloride, methionine, phenylalanine, tryptophan, starch, sodium carboxymethyl starch, magnesium stearate, sodium carboxymethyl cellulose, suspension A and suspension B. Thepreparation method comprises the steps of preparing a tablet core, preparing a separation layer and preparing an enteric coating layer. The compound amino acid enteric-coated tablets reduce adverse reactions caused by irritation to the stomach, supplements the dog's demand for amino acids, and has a simple preparation method. The preparation method is suitable for preparing the compound amino acid enteric-coated tablets for dogs, and the prepared compound amino acid enteric-coated tablets are suitable for dogs.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and relates to the field of animal husbandry and veterinary medicine, in particular to a compound amino acid enteric-coated tablet for dogs and a preparation method thereof. Background technique [0002] Nowadays, more and more families choose to domesticate dogs as pets, but some dogs are weak and sick. Under normal circumstances, they often show symptoms such as decreased appetite, reduced food intake, and physical weakness. If the above symptoms are not improved in time, it will lead to slow growth or even death of the dog. [0003] At present, the replenishment liquids used to enhance the dog's physical performance are mainly glucose and sodium chloride injections. The injections mainly play the role of replenishing water and energy, and regulating the balance of body electrolytes, but they cannot improve the nutritional status of the dog body and supplement the body's nutrients. Am...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K47/36A61K31/4172A61P3/02A61K31/198A61K31/401A61K31/405
CPCA61K31/4172A61K31/198A61K31/401A61K31/405A61K9/28A61K9/2059A61K9/2054A61P3/02A61K2300/00
Inventor 裴有志陈淑芳李凤英
Owner HEBEI KEXING PHARMA
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