Antimicrobial Polymethylmethacrylate Bone Cement
A bone cement, antibacterial technology, applied in the field of antibacterial compositions, can solve the problems of accumulation, degradation, inability of cationic antibacterial agents, etc.
Inactive Publication Date: 2016-08-24
HERAEUS MEDICAL
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Problems solved by technology
However, the issue to be discussed in this case is that said cationic antimicrobials cannot be degraded by human tissue and there is a risk of local accumulation
Method used
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[0112] The invention is explained in more detail in the examples set forth below, which do not, however, limit the scope of the invention.
[0113] The following examples were performed using Palacos® R cement powder (Lot B7457), PMMA cement powder. Urea-peroxide adduct and calcium peroxide were obtained from Sigma-Aldrich.
[0114] In each case, 10.0 g of Palacos® R cement powder and finely powdered urea-peroxide adduct or calcium peroxide were weighed out and placed in a 100 ml plastic container with a screw cap and subsequently placed in Mix in a Turbula mixer for 30 minutes. The compositions of Examples 1-9 are listed in the following two tables.
[0115] Subsequently, the mixtures were each mixed with 5 ml of Palacos monomer liquid, which is a monomer liquid. Forms a non-stick joint compound dough within 60 seconds. The cement dough was then pasted into cylindrical plastic molds. The cylindrical test body (12 mm high, 6 mm in diameter) was taken out after the curing ...
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Abstract
Composition is hardenable and comprises component(s) which is oxidizing compound or capable of releasing oxidizing compound in presence of water. Independent claims are included for the following: (1) kit, which comprises paste (A) and paste (B). The paste (A) contains radical polymerizable monomer(s) (a1), organic polymer(s) (a2) soluble in radical polymerizable monomer(s) (a1), and polymerization inhibitor(s) (a3). The paste (B) contains radical polymerizable monomer(s) (b1), organic polymer(s) (b2) soluble in radical polymerizable monomer(s) (b1), and polymerization accelerator(s) (b3). At least one of paste (A) and / or (B) contains hydrogen peroxide compound (s) as component (a4) or (b4); (2) hardenable bone cement, which is obtained by mixing paste (A) and (B), or powder component (C) and monomer component (D); and (3) molded article, which is obtained by polymerizing the composition or by mixing paste (A) and (B), or powder component (C) and monomer component (D) and polymerizing.
Description
technical field [0001] The present invention proposes an antimicrobial composition for use as a bone cement, in particular an antimicrobial polymethylmethacrylate bone cement, which can be cured and which comprises an amount of at least one of the following components: the A component is a compound having an oxidizing effect or a compound from which a compound having an oxidizing effect can be released. Preferably, it is hydrogen peroxide or releasable hydrogen peroxide. In this case, particular preference is given to using hydrogen peroxide adducts or salts which release hydrogen peroxide in the presence of water or aqueous conditions. Antimicrobial polymethylmethacrylate bone cement can be used for mechanical fixation of primary total articular endoprostheses, for mechanical fixation of revision total articular endoprostheses, and for production positioning objects (spacers). [0002] The subject of the present invention is an antimicrobial polymethylmethacrylate bone cem...
Claims
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IPC IPC(8): A61L27/16A61L27/02A61L27/54A61L31/02A61L31/04A61L31/16A61K47/32A61K47/04
CPCA61K33/40A61L24/0015A61L2300/11A61L2430/02C08L33/12C08L2312/00
Inventor S.福格特K-D.屈恩
Owner HERAEUS MEDICAL