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Application and use method of salidroside in preparing skin-care product for preventing skin photoaging

A technology of skin photoaging and salidroside, applied in skin care preparations, cosmetics, cosmetic preparations, etc., can solve problems such as tumor occurrence, achieve high water solubility, prevent skin photoaging, and improve skin permeability Effect

Inactive Publication Date: 2014-06-04
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

EGFR is involved in regulating multiple biological processes such as cell proliferation, anti-apoptosis, migration and angiogenesis, and plays a very important role in maintaining normal skin functions, but its abnormal regulation can lead to tumorigenesis. Numerous cancer research results have proved that the inhibition of EGFR Can treat cancer

Method used

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  • Application and use method of salidroside in preparing skin-care product for preventing skin photoaging
  • Application and use method of salidroside in preparing skin-care product for preventing skin photoaging
  • Application and use method of salidroside in preparing skin-care product for preventing skin photoaging

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: Salidroside anti-photoaging test

[0017] After resuscitating a purchased human keratinocyte, expand culture, grow for 3 generations, take half of the cells in a 6cm-diameter petri dish and spread them to a 24-well culture plate, and keep the remaining cells for cryopreservation. After the cell adherent growth density reached 60% in the 24-well culture plate, they were divided into negative control group, positive control group (all-trans retinoic acid) and experimental group (0.5% salidroside solution). And the experimental group added drugs, co-cultivated 24hr. After 24 hours, part of the control group and the experimental group sucked off the medium and added Trizol 500ul for total RNA extraction analysis, pipetting and transferring to a centrifuge tube to freeze to -20°C, the other part of the control group and the experimental group removed the medium, and then added PBS, UVB ultraviolet treatment, the dose is 30mj / cm2, and finally return to the cond...

Embodiment 2

[0021] Preparation of embodiment 2 anti-photoaging emulsion

[0022] In the present embodiment, emulsion formula is as follows:

[0023]

[0024]

[0025] Preparation method: Heat phases A and B to 80-85 degrees to dissolve completely, then add phase A to phase B for homogenization, and at the same time add phase C which is evenly mixed, homogenize for 5-10 minutes, after homogenization Stir in a water bath and keep warm for 30 minutes, then add other substances in phase D when the temperature drops below 50 degrees, stir evenly, and cool to room temperature.

Embodiment 3

[0026] Embodiment 3 Preparation of anti-photoaging moisturizing water

[0027] The recipe for this implementation is as follows:

[0028]

[0029] Preparation method: add the above-mentioned raw materials into sterilized deionized water in sequence, and stir while adding until transparent.

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Abstract

The invention discloses an application and use method of salidroside in preparing a skin-care product for preventing skin photoaging. When the skin-care product is prepared, the salidroside can be taken as an active matter and prepared into a salidroside liposome with the grain diameter less than 200 nanometers, and the mass percent concentration of the salidroside liposome is 0.01%-10%. According to the application and the use method disclosed by the invention, the influence of the salidroside on the expression of a UVB (Ultraviolet B) induced skin keratinocyte photoaging key gene is inspected, a test result indicates that the skin-care product effectively inhibits the degradation of collagen and the inflammatory reaction of cells and achieves the effect of preventing the skin photoaging; the salidroside is one of main components of rhodiola sachalinensis, and the salidroside can be directly added to the skin-care product for preventing the skin photoaging, or a salidroside extract which contains the salidroside can be indirectly added to the skin-care product for preventing the skin photoaging.

Description

technical field [0001] The invention belongs to the field of biotechnology, and specifically relates to the application and application method of salidroside in the preparation of skin care products for preventing skin photoaging. Background technique [0002] Skin photoaging is the premature aging of the skin caused by repeated exposure to the sun's ultraviolet rays. Acute exposure to UV rays from the sun can lead to sunburn (erythema), suppression of the immune system, DNA damage, and degradation of connective tissue, and long-term chronic UV exposure can cause photoaging of the skin, which can lead to skin cancer. With the deterioration of the environment and the reduction of the ozone layer, the amount of ultraviolet radiation irradiating the ground in the sun is gradually increasing, the phenomenon of photoaging of human skin is becoming more and more serious, and the incidence of skin cancer is increasing year by year, which seriously threatens the health of human skin...

Claims

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Application Information

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IPC IPC(8): A61K8/60A61Q19/08
Inventor 周华锋段明星姜梅高杨严泽民徐之伟
Owner TSINGHUA UNIV
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