Medicinal composition for establishing hyperuricemia animal model and application thereof

Abstract

The invention discloses a medicinal composition for establishing a hyperuricemia animal model and an application thereof. The medicinal composition comprises ethambutol and uric acid, and can be used for preparing an acute hyperuricemia model with short modeling time, stable model and high modeling success rate. The medicinal composition is administrated to a rhesus monkey in an intragastric manner, a stable and reliable acute hyperuricemia model can be quickly obtained, and the modeling method is reasonable and close to the pathogenesis of human beings.

Description

technical field [0001] The invention belongs to the field of biology, and relates to a pharmaceutical composition for establishing an animal model of hyperuricemia and its application. technical background [0002] Hyperuricemia refers to a state of the body in which the concentration of uric acid in the blood exceeds the normal range. Hyperuricemia is the most important biochemical basis of gout, prone to gouty arthritis, tophi deposition and joint deformity. Gout is a group of heterogeneous diseases caused by purine metabolism disorder and decreased excretion of uric acid, clinically characterized by hyperuricemia. [0003] In the human uric acid metabolism pathway, uric acid is the end product of human purine metabolism. There are two sources of uric acid in the human body, uric acid is synthesized in the body, or uric acid is produced by nucleic acid decomposition (endogenous), accounting for about 80% of the total uric acid in the body. Purine or nucleotides in food a...

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Problems solved by technology

It has something in common with humans in terms of uric acid synthesis and metabolism: but there is a large gap with humans in terms of species, and it is not convenient to raise in ordinary laboratories

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