Supercharge Your Innovation With Domain-Expert AI Agents!

Polymorphic substance of alpha-lipoic acid as well as preparation method and application of polymorphic substance

A technology of lipoic acid and crystals, which can be used in applications, food preparation, medical preparations containing active ingredients, etc., and can solve problems such as poor thermal stability

Inactive Publication Date: 2014-06-25
NANJING REAL PHARMA
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The melting point of ɑ-lipoic acid is 58-61 ° C, poor thermal stability, easy to polymerize under aerobic conditions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Polymorphic substance of alpha-lipoic acid as well as preparation method and application of polymorphic substance
  • Polymorphic substance of alpha-lipoic acid as well as preparation method and application of polymorphic substance
  • Polymorphic substance of alpha-lipoic acid as well as preparation method and application of polymorphic substance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Preparation of ɑ-lipoic acid crystal Ⅰ

[0027] 4.5g of lipoic acid was added to 40ml of n-hexane and 10ml of ethyl acetate, and stirred in a water bath at 50°C for 1 hour. The solution was cooled to 20°C, filtered, and dried under vacuum to obtain 2.9 g of crystal I with a yield of 64.44%.

[0028] PXRD pattern of crystal Ⅰ (radiation source is CuKα 1 )for figure 1 As shown, there are diffraction peaks at 2θ values ​​of 7.96, 11.92, 13.88, 17.82, 18.20, 23.32, 23.98, 24.46, 25.60, 31.66, 32.16, 40.52, 43.86, 49.06, and the error range of 2θ values ​​is ±0.2.

[0029] The DSC spectrum of crystal Ⅰ is as follows figure 2 As shown, there is an endothermic peak at 64.50±5.0°C.

Embodiment 2

[0030] Example 2 Preparation of ɑ-lipoic acid crystal Ⅱ

[0031] 4.1g of lipoic acid was added to 25ml of petroleum ether and 7.5ml of ethyl acetate, and stirred in a water bath at 50°C for 1 hour. The solution was cooled to 20°C, filtered, and vacuum-dried to obtain 2.5 g of crystal II with a yield of 60.98%.

[0032] PXRD pattern of crystal Ⅱ (radiation source is CuKα 1 )Such as image 3 As shown, there are diffraction peaks at 2θ values ​​of 11.88, 13.86, 17.26, 17.80, 18.16, 20.78, 23.32, 23.92, 25.60, 27.96, 28.96, 36.06, and the error range of 2θ values ​​is ±0.2.

[0033] The DSC spectrum of crystal Ⅱ is Figure 4 , It has an endothermic peak at 62.74±5.0℃.

Embodiment 3

[0034] Example 3 ɑ-lipoic acid crystal Ⅰ tablets

[0035] prescription:

[0036]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a polymorphic substance of alpha-lipoic acid as well as a preparation method and an application of the polymorphic substance. The polymorphic substance has novel spectral line characteristics in a powder X-ray diffraction spectrum. The polymorphic substance can be applied to medicine production, food additives and healthcare products.

Description

technical field [0001] The invention relates to a polymorph of α-lipoic acid, a preparation method and application of the polymorph. Background technique [0002] Polymorphism refers to the phenomenon that solid substances form solid states with different physical and chemical properties in two or more different spatial arrangements. Drug molecules often exist in different solid forms, including salts, polymorphs, co-crystals, amorphous, hydrates, and solvates. Different crystal forms of the same drug will have significant differences in terms of crystal structure, stability, dissolution, dissolution performance, manufacturability, and bioavailability, which will have an important impact on the efficacy and developability of the drug. In view of the importance of drug crystal forms, both FDA and SFDA have put forward clear regulations on this in drug declarations, requiring research on drug polymorphism and providing corresponding data. Therefore, the research and developm...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D339/04A61K31/385A61P3/10A23L1/30A23L33/10
CPCC07D339/04A23L33/10
Inventor 叶海晁阳包玉胜
Owner NANJING REAL PHARMA
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com