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Medicinal composition as well as preparation and application thereof

A composition and drug technology, applied in the field of medicine, can solve problems such as influence

Inactive Publication Date: 2014-07-16
ZHAOKE PHARMA GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies have shown that there are still many physiological factors or environmental factors that affect it
However, the current drugs for the treatment of dry eye are still unable to adjust these factors well.
In other words, the current drugs for the treatment of dry eye are still insufficient in terms of removing inflammatory mediators and promoting tear secretion.

Method used

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  • Medicinal composition as well as preparation and application thereof
  • Medicinal composition as well as preparation and application thereof
  • Medicinal composition as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Preparation of the suspension provided by the present invention for the treatment of dry eye disease

[0034] Take the following components:

[0035]

[0036]

[0037] Dissolve all the above ingredients except rebamipide in purified water, adjust the pH value to 6.0 with sodium hydroxide and hydrochloric acid, and filter the resulting solution through a sterile filter to sterilize.

[0038] Then add the sterilized rebamipide into the filtrate and stir to obtain a suspension for treating dry eye disease.

Embodiment 2

[0039] Example 2 Preparation of the suspension provided by the present invention for the treatment of dry eye disease

[0040] Take the following components:

[0041]

[0042] Dissolve all the above ingredients except rebamipide in purified water, adjust the pH value to 6.0 with sodium hydroxide and hydrochloric acid, and filter the resulting solution through a sterile filter to sterilize.

[0043] Then add the sterilized rebamipide into the filtrate and stir to obtain a suspension for treating dry eye disease.

Embodiment 3

[0044] Example 3 Preparation of the suspension provided by the present invention for the treatment of dry eye disease

[0045] Take the following components:

[0046]

[0047] Dissolve all the above ingredients except rebamipide in purified water, adjust the pH value to 6.0 with sodium hydroxide and hydrochloric acid, and filter the resulting solution through a sterile filter to sterilize.

[0048] Then add the sterilized rebamipide into the filtrate and stir to obtain a suspension for treating dry eye disease.

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PUM

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Abstract

The invention relates to the technical field of medicines, and in particular relates to a medicinal composition as well as a preparation and application thereof. The medicinal composition comprises a component a and a component b; the component a is rebamipide, pharmaceutically acceptable salt or isomeride thereof; and the component b is ciclosporin A, pharmaceutically acceptable salt or isomeride thereof. Experiments prove that a synergistic effect can be achieved when the rebamipide and the ciclosporin A are used together. The composition significantly improves the effects of promoting lacrimal secretion and eliminating inflammation compared with the effects achieved when the rebamipide and the ciclosporin A are used separately (P<0.05). Therefore, when the rebamipide and the ciclosporin A are compounded to prepare the medicament for treating xerophthalmia, the treatment effect can be improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition and its preparation and application. Background technique [0002] Dry eye syndrome refers to the general term for various diseases that are caused by abnormal tear quality or quantity or dynamics caused by any reason, resulting in a decrease in the stability of the tear film, accompanied by ocular discomfort and (or) ocular surface tissue lesions. Keratoconjunctival xerosis. The pathophysiological manifestations of dry eye disease are diverse, including: inflammation, decreased tear secretion, decreased mucin secretion, and decreased number of conjunctival goblet cells. Epidemiological studies have shown that 10% to 20% of adults suffer from dry eye disease. In recent years, the incidence of dry eye syndrome in my country has gradually increased and is developing towards a younger age. At present, the drugs commonly used in the treatment of dry e...

Claims

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Application Information

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IPC IPC(8): A61K38/13A61P27/02A61K31/4704
Inventor 戴向荣叶文锐李小羿张国辉
Owner ZHAOKE PHARMA GUANGZHOU
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