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Scutellaria baicalensis total flavonoid sustained release tablet and preparation method thereof

A technology of total flavonoids of Scutellaria baicalensis and sustained-release tablets, which is applied in the direction of medical formulas, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., which can solve the inconvenience of taking patients, gastric mucosal irritation, and affect patients' medication compliance and other problems, to achieve the effect of reducing the number of times of taking medicine, reducing side effects, slow and lasting drug release process

Inactive Publication Date: 2014-07-23
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently commercially available Huangqin Tablets or Compound Huangqin Tablets need to be taken 3 to 4 times a day, which to a certain extent causes inconvenience for patients to take. At the same time, after using Huangqin Tablets, Compound Huangqin Tablets can stimulate the gastric mucosa to a certain extent and affect the patient's medication compliance.

Method used

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  • Scutellaria baicalensis total flavonoid sustained release tablet and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 Scutellaria baicalensis total flavonoids sustained release tablet

[0027] 1) Extraction and purification process of total flavonoids from Scutellaria baicalensis:

[0028] Take Scutellaria baicalensis, cut into slices, decoct and extract twice with 10 times the amount of water, 1.5 hours each time, combine the extracts, absorb with macroporous adsorption resin, first wash with 4 times the amount of water to remove impurities, and then use 8 times the amount of 50% ethanol The solution was eluted, and the alcohol eluate was collected, concentrated, and dried to obtain the total flavonoids extract of Scutellaria baicalensis.

[0029] 2) Scutellaria baicalensis total flavonoids sustained-release tablet preparation process:

[0030] Scutellaria baicalensis total flavonoids extract 200g

[0031] Hypromellose K1500 200g

[0032] Microcrystalline Cellulose 590g

[0033] Sodium Lauryl Sulfate 5g

[0034] Talc powder 5g

[0035] 70% ethanol...

Embodiment 2

[0037] The preparation of embodiment 2 Scutellaria baicalensis total flavonoids sustained release tablet

[0038] 1) Extraction and purification process of total flavonoids from Scutellaria baicalensis:

[0039] Take Scutellaria baicalensis, cut into slices, decoct and extract twice with 10 times the amount of water, 1.5 hours each time, combine the extracts, absorb with macroporous adsorption resin, wash with 4 times the amount of water to remove impurities, and then use 8 times the amount of 70% ethanol The solution was eluted, and the alcohol eluate was collected, concentrated, and dried to obtain the total flavonoids extract of Scutellaria baicalensis.

[0040] 2) Scutellaria baicalensis total flavonoids sustained-release tablet preparation process:

[0041] Scutellaria baicalensis total flavonoids extract 200g

[0042] Hypromellose K750 280g

[0043] Microcrystalline Cellulose 510g

[0044] Sodium Lauryl Sulfate 5g

[0045] Magnesium Stearate 5g

[0046] 70% ethanol...

Embodiment 3

[0048] The preparation of embodiment 3 Scutellaria baicalensis total flavonoids sustained release tablet

[0049] 1) Extraction and purification process of total flavonoids from Scutellaria baicalensis:

[0050] Take Scutellaria baicalensis, cut into slices, decoct and extract twice with 10 times the amount of water, 1.5 hours each time, combine the extracts, absorb with macroporous adsorption resin, wash with 4 times the amount of water to remove impurities, and then use 8 times the amount of 70% ethanol The solution was eluted, and the alcohol eluate was collected, concentrated, and dried to obtain the total flavonoids extract of Scutellaria baicalensis.

[0051] 2) Scutellaria baicalensis total flavonoids sustained-release tablet preparation process:

[0052] Scutellaria baicalensis total flavonoids extract 400g

[0053] Ethyl cellulose 300g

[0054] Microcrystalline Cellulose 180g

[0055] Lactose 100g

[0056] Tween-80 10g

[0057] Magnesium Stearate 10g

[0058] P...

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Abstract

The invention discloses a scutellaria baicalensis total flavonoid sustained release tablet and a preparation method thereof, belonging to the field of Chinese medicine preparations. The scutellaria baicalensis total flavonoid sustained release tablet consists of the following components in percentage by weight: 20-50% of a scutellaria baicalensis total flavonoid extract, 20-40% of a sustained release framework material and 10-50% of pharmaceutical adjuvants, wherein the scutellaria baicalensis total flavonoid extract is determined through an ultraviolet spectrophotometry and contains not less than 60% of total flavonoid in terms of baicalin; a high performance liquid chromatography (HPLC) determines that content of a baicalin monomer is not less than 40%. In addition, the invention also discloses a method for preparing the scutellaria baicalensis total flavonoid sustained release tablet. The method mainly comprises the processes of extracting and separating the scutellaria baicalensis total flavonoid extract and preparing the sustained release tablet. Compared to a current commercial scutellaria baicalensis tablet, the scutellaria baicalensis total flavonoid sustained release tablet disclosed by the invention can significantly reduce a drug release speed, prolong release time and keep a stable blood concentration; moreover, the sustained release tablet can reduce administration time, reduce side effect and improve a medication compliance of patients.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a sustained-release tablet of total flavonoids from Scutellaria baicalensis and a preparation method thereof. Background technique [0002] Scutellaria baicalensis is the dry root of Scutellaria baicalensis Georgi, a plant of the Labiatae family. It tastes bitter and is cold in nature. Used for dampness-heat, summer-dampness, chest tightness and nausea, damp-heat fullness, dysentery, jaundice, cough due to lung-heat, high fever and polydipsia, blood-heat vomiting at the nose, carbuncle sores, restless fetal movement. [0003] The chemical constituents of Scutellaria baicalensis are mainly flavonoids represented by baicalin, such as baicalin, wogonoside, baicalein, wogonin, norwogonin, celestialin A, celestialin A glycosides and luteolin etc. In addition, Scutellaria baicalensis also contains phenylethyl alcohol glycosides, lignan gl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K36/539A61K47/38
Inventor 赵志全孙宗喜乔建卫李蔚群
Owner LUNAN PHARMA GROUP CORPORATION
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