Application of indinavir in preparing medicament for preventing or treating acute lung injury/acute respiratory distress syndrome and pulmonary fibrosis
A technology for acute respiratory distress and acute lung injury, which is applied in the application field of indinavir in the preparation of drugs for preventing or treating acute lung injury/acute respiratory distress syndrome and pulmonary fibrosis, and can solve the pharmacological problems of indinavir. The effect has not been reported and other issues
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Embodiment 1
[0012] Example 1 Preparation of Indinavir Sulfate Freeze-Dried Powder for Injection
[0013] Take 50.0g of indinavir sulfate, add 2000ml of water for injection to dissolve it, add 8g of mannitol, stir to dissolve, and ultra-filter to obtain a clear liquid without pyrogen, pour it into a 10ml vial, 2ml / bottle, press the freeze-dried powder Freeze-dried by needle process to make freeze-dried powder injections each containing 50.0 mg of indinavir sulfate.
Embodiment 2
[0014] Example 2 Preparation of Indinavir Sulfate Capsules
[0015] Weigh 100.0g of indinavir sulfate, and 100.0g of carboxymethyl starch sodium, mix well and pass through a 100 mesh sieve, add an appropriate amount of 3% PVP K30 Appropriate amount of water solution to prepare soft material, granulate with 20-mesh sieve, dry at 60°C for 3 hours, sieve with 18-mesh sieve for granulation, add 2.0g of magnesium stearate, mix well and pack into capsules, adjust the weight of the capsules to about 200mg.
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