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Medicine composition for preventing and treating migraine disease as well as preparation method and application of medicine composition

A technology of migraine and medicine, which is applied in the field of traditional Chinese medicine drug substance combination which has the effect of preventing and treating migraine, and can solve the problems of no anti-migraine drug substance combination and migraine disease research reports.

Active Publication Date: 2014-08-20
石任兵 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the purification and preparation of anti-migraine drug substance combination from Bai Zhi Fang, and there is no relevant research report on the composition in the treatment of migraine diseases

Method used

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  • Medicine composition for preventing and treating migraine disease as well as preparation method and application of medicine composition
  • Medicine composition for preventing and treating migraine disease as well as preparation method and application of medicine composition
  • Medicine composition for preventing and treating migraine disease as well as preparation method and application of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Anti-migraine effect of effective components on nitroglycerin-induced migraine model rats

[0029] There are 30 SD rats, half male and half male, divided into 3 groups, 10 rats in each group, namely blank group, model group, and Chinese medicine preparation group. Replicate the nitroglycerin migraine model (10mg / kg), administer intragastrically immediately after modeling, take blood from the abdominal aorta immediately after 15 minutes, centrifuge to obtain plasma, then take the brain, and determine the content of calcitonin gene-related peptide in the brain ( CPGR) (measured by ELISA method), endothelin content (ET-1) (measured by ELISA method), NO content (measured by biochemical method), plasma serotonin (5-HT) content (measured by ELISA method).

[0030] Experimental results: Comparison of 5-HT content in plasma and CGRP, NO, ET in brain of rats in each group

[0031]

[0032] Note: Compared with model group **P <0.01.

[0033] in conclusion

[0034] Compared wit...

Embodiment 2

[0054] Example 2: Preparation process of traditional Chinese medicine drug substance combination for preventing and treating migraine

[0055] Bai Zhi 454g Ligusticum 273g

[0056] Gastrodia 273g

[0057] Take 1 kg of crude drug pieces according to the above ratio, extract 1 time with 80% ethanol 8 times the amount of reflux, extract for 0.5 hours each time, and recover the solvent under reduced pressure to obtain the extract; add water to disperse and dissolve so that the concentration of the aqueous solution is 0.05g / mL (based on crude drug Meter), through 4L AB-8 type macroporous adsorption resin, adsorption flow rate 2BV / h, resin column diameter-to-height ratio of 1:6, loading solution concentration of 0.05g / ml, water elution 3 times the volume of resin for removal Impurity removal flow rate is 3BV / h, 50% ethanol elution 6 times the resin volume, elution flow rate is 2BV / h, collect 50% ethanol eluate, recover the solvent, dry under reduced pressure to obtain phthalides and pheno...

Embodiment 3

[0064] Example 3: Preparation process of traditional Chinese medicine drug substance combination for preventing and treating migraine

[0065] Bai Zhi 454g Ligusticum 273g

[0066] Gastrodia 273g

[0067] Take 1kg of crude drug pieces according to the above ratio, extract 3 times with 8 times the amount of 60% ethanol and reflux for 1.5 hours each time. Recover the solvent under reduced pressure to obtain the extract; add water to disperse and dissolve so that the concentration of the aqueous solution is 0.05g / mL (based on crude drug Meter,), through 4L AB-8 type macroporous adsorption resin, adsorption flow rate 2BV / h, resin column diameter to height ratio of 1:6, sample concentration of 0.05g / ml, water elution 4 times the volume of the resin In addition, the impurity removal flow rate is 3BV / h, 55% ethanol elution is 6 times the resin volume, and the elution flow rate is 2BV / h. Collect the 50% ethanol eluate, recover the solvent, and dry under reduced pressure to obtain phthalides...

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Abstract

The invention belongs to the field of research and development of a traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for preventing and treating a migraine disease as well as preparation method and an application of the medicine composition. The traditional Chinese medicine composition is prepared from medicines screened based on a traditional Chinese medicine clinical experience formula, namely a radix angelicae formula and is obtained by ethanol extraction according to the radix angelicae formula and purification and enrichment of macroporous adsorption resin. Main components of the traditional Chinese medicine composition are coumarins, phenolic acids and phthalide. Pharmacological experiments prove that the traditional Chinese medicine composition can be used for increasing the content of 5-HT in plasma of nitroglycerin-induced migraine model rats and the content of NO in brains of the rats, and reducing the content of calcitonin gene-related peptides in the brains of the rats and the content of endothelin in the brains of the rats, so that the migraine is prevented and treated.

Description

Technical field [0001] The invention relates to a combination of traditional Chinese medicine and drug substances, in particular to a combination of traditional Chinese medicine and drug substances with the effects of preventing and treating migraine, and a method for preparing the combination simultaneously. The invention belongs to the field of drug research and development. Background technique [0002] Migraine, also known as angio-neuropathic headache, is a common clinical disease characterized by severe, left or right, repeated occurrences of headaches. Epidemiological surveys show that the incidence of migraine in China is 985.2 per 100,000, and the annual incidence is 79.5 per 100,000. The incidence of people over 30 years old has an upward trend year by year, and the economic loss caused by this throughout the year is as high as 130 Billion US dollars. At present, the exact pathophysiological mechanism of migraine onset by western medicine is still not very clear, althou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A61P25/06
Inventor 石任兵王永炎左胜彭平姜艳艳孙雅姝迟蕾张璐李焕娟
Owner 石任兵
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