Medicine composition for preventing and treating migraine disease as well as preparation method and application of medicine composition
A technology of migraine and medicine, which is applied in the field of traditional Chinese medicine drug substance combination which has the effect of preventing and treating migraine, and can solve the problems of no anti-migraine drug substance combination and migraine disease research reports.
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Embodiment 1
[0028] Example 1: Anti-migraine effect of effective components on nitroglycerin-induced migraine model rats
[0029] There are 30 SD rats, half male and half male, divided into 3 groups, 10 rats in each group, namely blank group, model group, and Chinese medicine preparation group. Replicate the nitroglycerin migraine model (10mg / kg), administer intragastrically immediately after modeling, take blood from the abdominal aorta immediately after 15 minutes, centrifuge to obtain plasma, then take the brain, and determine the content of calcitonin gene-related peptide in the brain ( CPGR) (measured by ELISA method), endothelin content (ET-1) (measured by ELISA method), NO content (measured by biochemical method), plasma serotonin (5-HT) content (measured by ELISA method).
[0030] Experimental results: Comparison of 5-HT content in plasma and CGRP, NO, ET in brain of rats in each group
[0031]
[0032] Note: Compared with model group **P <0.01.
[0033] in conclusion
[0034] Compared wit...
Embodiment 2
[0054] Example 2: Preparation process of traditional Chinese medicine drug substance combination for preventing and treating migraine
[0055] Bai Zhi 454g Ligusticum 273g
[0056] Gastrodia 273g
[0057] Take 1 kg of crude drug pieces according to the above ratio, extract 1 time with 80% ethanol 8 times the amount of reflux, extract for 0.5 hours each time, and recover the solvent under reduced pressure to obtain the extract; add water to disperse and dissolve so that the concentration of the aqueous solution is 0.05g / mL (based on crude drug Meter), through 4L AB-8 type macroporous adsorption resin, adsorption flow rate 2BV / h, resin column diameter-to-height ratio of 1:6, loading solution concentration of 0.05g / ml, water elution 3 times the volume of resin for removal Impurity removal flow rate is 3BV / h, 50% ethanol elution 6 times the resin volume, elution flow rate is 2BV / h, collect 50% ethanol eluate, recover the solvent, dry under reduced pressure to obtain phthalides and pheno...
Embodiment 3
[0064] Example 3: Preparation process of traditional Chinese medicine drug substance combination for preventing and treating migraine
[0065] Bai Zhi 454g Ligusticum 273g
[0066] Gastrodia 273g
[0067] Take 1kg of crude drug pieces according to the above ratio, extract 3 times with 8 times the amount of 60% ethanol and reflux for 1.5 hours each time. Recover the solvent under reduced pressure to obtain the extract; add water to disperse and dissolve so that the concentration of the aqueous solution is 0.05g / mL (based on crude drug Meter,), through 4L AB-8 type macroporous adsorption resin, adsorption flow rate 2BV / h, resin column diameter to height ratio of 1:6, sample concentration of 0.05g / ml, water elution 4 times the volume of the resin In addition, the impurity removal flow rate is 3BV / h, 55% ethanol elution is 6 times the resin volume, and the elution flow rate is 2BV / h. Collect the 50% ethanol eluate, recover the solvent, and dry under reduced pressure to obtain phthalides...
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